Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Estrogen-protective effect on lymphatic endothelium is mediated by the estrogen receptor (ER) α. Schematic representation of the molecular mechanisms implicated in the pro-lymphangiogenic effects of E2. The binding of E2 to ERα stimulates the transcription of lymphangiogenic genes through the genomic pathway. Additionally, E2 treatment activates Erk pathway and increases LEC migration and tubulogenesis.
