Table 1.
Thermo-responsive scaffolds for drug delivery in wound healing.
| Polymer System | Delivered Drug | Application | Release Time | Ref |
|---|---|---|---|---|
| Gelatin | Ibuprofen | Inflammation and bone regeneration | 100 h | [219] |
| PLGA | Ibuprofen | Inflammation | 30 h | [220] |
| Poly(N-vinylcaprolactam-co-methacrylic acid) | Ketoprofen | Inflammation | 50 h | [221] |
| Poly(di(ethylene glycol) methyl ether methacrylate), Ethyl cellulose | Ketoprofen | Inflammation | 100 h (80%) | [222] |
| Sodium alginate | Celecoxib | Hyperthermia | - | [223] |
| Chitosan, PCL | Ferulic acid, resveratrol | Inflammation, pro-angiogenic | 120 h (55% of ferulic acid and 48% of resveratrol) | [224] |
| PVA, chitosan | Tetracycline HCl | Bacterial infection | 4 h (80%) | [225] |
| Chitosan, PEG | Ciprofloxacin HCl | Bacterial infection | 20 h (30%) | [226] |
| Chitosan, alginate | Alpha-tocoferol | Skin injuries, oxidative process | 14 days (77%) | [227] |
| Eudragit | Gentamicin sulphate | Bacterial infection in diabetic ulcer | 12 h (90% at acid pH) | [228] |
| PLGA | Clorhexidine | Infection treatment | 50 days | [229] |
| Chitosan | Vamcomycin | Bacterial infection, osteomyelitis | 26 days | [230] |
| PCL, silk fibroin | Amoxicillin | Bacterial infection | 14 days | [231] |
| PLGA, poly(L-lactic acid) | Doxycycline | Bacterial infection | 6 weeks | [232] |
| PVA | Tetracycline | Bacterial infection | 24 h (82% at pH 7.4) | [233] |