Table 2.
The 10 most common non-BGP PVs and their frequency difference in the BGP and non-BGP carriers.
| Non-BGP PV | Non-BGP Carriers (%) | BGP Carriers (%) | BGP—Non-BGP Frequency Difference (95%CI) | p-Value |
|---|---|---|---|---|
| BRCA1:c.5266dupC | 83 (9.0) | 1 (1.0) | −8 (−10.2 to −3.3) | 0.0056 |
| BRCA1:c.190T>C | 21 (2.3) | 34 (34.0) | 31.7 (23.1 to 41.5) | <0.0001 |
| BRCA1:c.5062_5064delGTT | 10 (1.1) | 6 (6.0) | 4.9 (1.6 to 11.4) | 0.0002 |
| BRCA2:c.8878C>T | 26 (2.8) | 8 (8.0) | 5.2 (1.1 to 12.2) | 0.0063 |
| BRCA2:c.7180A>T | 16 (1.7) | 4 (4.0) | 2.3 (−0.4 to 8.1) | 0.1219 |
| BRCA1:c.5030_5033delCTAA | 17 (1.8) | 4 (4.0) | 2.2 (−0.5 to 8) | 0.1509 |
| BRCA1:c.1088delA | 25 (2.7) | 0 (0.0) | −2.7 (−4 to 1.1) | 0.0951 |
| BRCA1:c.181T>G | 20 (2.2) | 0 (0.0) | −2.2 (−3.3 to 1.6) | 0.1361 |
| BRCA2:c.5796_5797delTA | 15 (1.6) | 0 (0.0) | −1.6 (−2.7 to 2.1) | 0.1986 |
| BRCA1:c.3257T>G | 15 (1.6) | 0 (0.0) | −1.6 (−2.7 to 2.1) | 0.1986 |