Table 4.
Genotype frequencies of the gene IL-8 −251 T > A rs4073 and prognostic factors of NB patients.
| Variables | Genotype Frequencies n (%) SNP IL-8 rs4073 | |||||
|---|---|---|---|---|---|---|
| TT | TA | AA | TT + TA | TA + AA | ||
| INSS stage | E1 | 2 (7.4) | 2 (7.4) | 1 (3.7) | 4 (14.8) | 3 (11.1) |
| E2b | 1 (3.7) | 1 (3.7) | ---- | 2 (7.4) | 1 (3.7) | |
| E3 | 1 (3.7) | 6 (22.2) | ---- | 7 (25.9) | 6 (22.2) | |
| E4 | 4 (14.8) | 3 (11.1) | 6 (22.2) | 7 (25.9) | 9 (33.3) | |
| p value | 0.1 | 0.12 | 0.69 | |||
| INRG | L1 | 3 (11.1) | 2 (7.4) | ----- | 5 (18.5) | 2 (7.4) |
| L2 | 1 (3.7) | 6 (22.2) | 1 (3.7) | 7 (25.9) | 7 (25.9) | |
| M | 4 (14.8) | 4 (14.8) | 6 (22.2) | 8 (29.6) | 10 (37) | |
| p value | 0.1 | 0.12 | 0.21 | |||
| Risk | Low | 3 (11.1) | 2 (7.4) | 5 (18.5) | 2 (7.4) | |
| Intermediate | 2 (7.4) | 4 (14.8) | 1 (3.7) | 6 (22.2) | 5 (18.5) | |
| High | 3 (11.1) | 6 (22.2) | 6 (22.2) | 9 (33.3) | 12 (44.4) | |
| p value | 0.3 | 0.24 | 0.28 | |||
| Differentiation | Undifferentiated | ----- | 2 (7.4) | ----- | 2 (7.4) | 2 (7.4) |
| Partially differentiated | 5 (18.5) | 8 (29.6) | 3 (11.1) | 13 (48.1) | 11 (40.1) | |
| Differentiated | 3 (11.1) | 1 (3.7) | 1 (3.7) | 4 (14.8) | 2 (7.4) | |
| Not specified | ---- | 1 (3.7) | 3 (11.1) | 1 (3.7) | 4 (14.8) | |
| p value | 0.17 | 0.14 | 0.23 | |||
| Histology (Shimada) | Favorable | 6 (22.2) | 8 (29.6) | 1 (3.7) | 14 (51.9) | 9 (33.3) |
| Unfavorable | 2 (7.4) | 4 (14.8) | 6 (22.2) | 6 (22.2) | 10 (37) | |
| p value | 0.04 | 0.02 | 0.23 | |||
| MYCN | Amplified | ---- | --- | 1 (3.7) | ---- | 1 (3.7) |
| Not amplified | 8 (29.6) | 12 (44.4) | 6 (22.2) | 20 (74.1) | 18 (66.7) | |
| p value | 0.1 | 0.2 | 1 | |||
| Metastasis | Yes | 4 (26.7) | 5 (18.5) | 6 (22.2) | 9 (33.3) | 11 (40.7) |
| No | 4 (26.7) | 7 (25.9) | 1 (3.7) | 11 (40.7) | 8 (29.6) | |
| p value | 0.2 | 0.09 | 1 | |||
P obtained by X2 analysis and Fisher exact test.