Table 1.
Results from univariate and multivariate Cox regression analysis adjusted for age, gender and BMI of prognostic factors associated with overall survival.
| Univariate Analyses (Adjusted for Age, Gender, BMI) |
Multivariate Analysis (Adjusted for Age, Gender, BMI) |
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|---|---|---|---|---|---|
| Variable | Mean (SD) or Frequency (%) |
Hazard Ratio [95%-C] | p-Value | Hazard Ratio [95%-CI] | p-Value |
| Age | 66 (10) | 1.024 [1.002, 1.047] |
0.0356 | ||
| Gender female |
80 (48.19) | 1.173 [0.789, 1.745] |
0.4297 | ||
| male | 86 (51.81) | ||||
| BMI | 25.7 (4.3) | 0.996 [0.954, 1.040] |
0.8547 | ||
| ASA <3 |
62 (37.35) | 0.909 [0.607, 1.362] |
0.6449 | ||
| ≥3 | 104 (62.65) | ||||
| Tumour grade G2 |
94 (56.63) | 1.954 [1.342, 2.844] |
0.0005 | ||
| G3 | 72 (56.63) | ||||
| Extent of tumour T1/T2 |
26 (15.66) | 2.116 [1.015, 4.410] |
0.0455 | ||
| T3/T4 | 140 (84.34) |
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| Perineural invasion Absent |
28 (16.87) | 2.239 [1.265, 3.961] |
0.0056 | 2.409 [1.337, 4.340] |
0.0034 |
| Present | 138 (83.13) |
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| Lymph node metastasis Absent |
39 (23.49) | 2.322 [1.407, 3.834] |
0.0010 | ||
| Present | 127 (76.51) | ||||
| Lymphatic invasion Absent |
114 (68.67) | 2.080 [0.418, 3.050] |
0.0002 | 1.763 [1.173, 2.651] |
0.0064 |
| Present | 52 (31.33) | ||||
| Venous invasion Absent |
136 (81.93) | 1.452 [0.923, 2.284] |
0.1068 | ||
| Present | 30 (81.93) | ||||
| Surgical margin status Negative |
106 (63.86) | 1.962 [1.342, 2.868] |
0.0005 | ||
| Positive | 60 (36.14) | ||||
| Nerve fiber density High |
72 (43.37) | 1.597 [1.093, 2.336] |
0.0155 | 1.676 [1.126, 2.495] |
0.0109 |
| Low | 94 (56.63) | ||||
| Lymphoid Aggregates <5 |
95 (57.23) | 1.084 [0.745, 1.577] |
0.6723 | ||
| ≥5 | 71 (42.77) | ||||
| Tumor cellularity | 0.36 (0.20) | 5.280 [1.952, 14.282] |
0.0010 | 4.287 [1.460, 12.589] |
0.0081 |
| Interaction between Lymph node metastasis and surgical margin status | 0.0053 | ||||
| lymph node metastasis present at surgical margin status positive | 0.587 [0.272, 1.266] |
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| lymph node metastasis present at surgical margin status negative | 2.618 [1.260, 5.437] |
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