Figure 6.
HSP90AA1 is deregulated in SARS-CoV-2 infected cells
(A) Correlation of gene expression values with the amount of SARS-CoV RNA (horizontal axis) and SARS-CoV-2 RNA (vertical axis) in the H1299 scRNA-seq data.
(B) Distribution of HSP90AA1 mRNA expression in H1299 single cell samples. For SARS-CoV and SARS-CoV-2 samples, cells were group by presence of viral RNAs. To calculate p values, the Kruskal-Wallis test was used (p.val < 1 × 10−5, with 3 degrees of freedom), followed by post-hoc comparison of classes using the Dunn test with Bonferroni correction. Non-significant (n.s.) indicates p values larger than 1 × 10−5.
(C and D) As in A, B, but for Calu-3 (4 hpi) samples.