Table 3.
The β-Lactam Antibiotic MIC Values and β-Lactamase Genes of Part of the Isolates Tested (Clavulanic Acid ≤4mg/L)
| Combination | MIC of β-Lactam Antibiotic(mg/L) | Efficacy* | Isolates Regaining Susceptibility | Isolates Failing to Regain Susceptibility | ||
|---|---|---|---|---|---|---|
| blaKPC-2 Only | blaKPC-2 Along with Other Genes** | blaKPC-2 Only | blaKPC-2 Along with Other Genes | |||
| Imipenem/clavulanic acid | 2 | 1/1 | 8 | 5 | 8 | 8 |
| 4 | 4/4 | |||||
| 8 | 8/24 | |||||
| Meropenem/clavulanic acid | 2 | 0/1 | 11 | 8 | 9 | 6 |
| 4 | 3/3 | |||||
| 8 | 7/9 | |||||
| 16 | 9/21 | |||||
| Ceftazidime/clavulanic acid | 8 | 3/3 | 3 | 5 | 7 | 3 |
| 16 | 5/15 | |||||
| Total | / | 19/39 | 11 | 8 | 11 | 9 |
Notes: *Efficacy=the number of the isolates regaining susceptibility/the total number of the isolates with β-lactam antibiotic MIC value shown in the second column. **the gene combinations include the following: blaKPC-2+blaCTX-M-Group1, blaKPC-2+blaCTX-M-Group1+ blaCTX-M-Group9, blaKPC-2+blaCTX-M-Group1+blaDHA, blaKPC-2+ blaCTX-M-Group9, blaKPC-2+ blaDHA, blaKPC-2+ blaDHA+ blaCTX-M-Group9, blaKPC-2+ blaDHA+ blaNDM.