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. 2021 Feb 2;16:741–752. doi: 10.2147/IJN.S277377

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© 2021 Liu et al.

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Effect of Q-MSNs on myocardial proteins in ischemia-reperfusion rats. (A) Effect of Q-MSNs on apoptosis-related proteins in myocardial tissues of ischemia-reperfusion rats. Both quercetin and Q-MSNs regulated apoptosis-related proteins, and at the same concentration, 40Q-MSNs had better regulation effect. (B) Effect of Q-MSNs on the JAK pathway in myocardial tissues of ischemia-reperfusion rats. Both quercetin and Q-MSNs exerted no effect on the total protein expression of JAK2 and STAT3, but can promote the phosphorylation of them, and at the same concentration, 40Q-MSNs had a better promotion effect. There were 10 rats in each group.

Notes: Compared with the IR group, *p<0.05, **p<0.01, ***p<0.001.

Abbreviations: JAK2, janus kinase 2; STAT3, signal transducer and activator of transcription 3; p-STAT3, phosphorylation of signal transducer and activator of transcription 3; MSNs, mesoporous silica nanoparticles without quercetin; 40Q-MSNs, 40 μmol/L quercetin-loaded mesoporous silica nanoparticles; 40Q, 40 μmol/L quercetin; IR, ischemia reperfusion.