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. 2021 Jan 31;26(3):737. doi: 10.3390/molecules26030737

Table 5.

Effect of 30-phosphate derivatives of betulonic acid 8, betulinic acid 9, and reference compounds on the viability of cells from two cancer cell lines studied (C-32 and SNB-19).

graphic file with name molecules-26-00737-i001.jpg

R 30-OP(O)(OC2H5)2 29-P(O)(OC2H5)2 * 30-P(O)(OC2H5)2 * H
R1 O=
Comp. 8 		OH
Comp. 9 		O= OH CH3C(O)O OH OH
IC50[µM] C-32 45.74 ± 6.85 NA 45.52 ± 3.72 47.46 ± 2.96 30.74 ± 2.17 NA 8.63 ± 0.90
SNB-19 45.75 ± 5.27 5.98 ± 0.43 1.64 ± 0.18 7.67 ± 1.57 1.29 ± 0.15 NA 20.09 ± 1.26

*—Phosphonate derivatives of betulonic and betulinic acids; synthesis and the results of the anti-HIV-1 activity test were described previously [9].NA Means IC50 > 50 µM.