Skip to main content
. 2021 Jan 31;26(3):746. doi: 10.3390/molecules26030746

Table 1.

Experimental solubilities (xe) of emtricitabine (ECT) in mole fraction in various pure solvents (PS) at T = 298.2 K to 318.2 K and p = 0.1 MPa a.

PS x e
T = 298.2 K T = 303.2 K T = 308.2 K T = 313.2 K T = 318.2 K
EA 3.63 × 10−4 5.34 × 10−4 7.12 × 10−4 9.96 × 10−4 1.28 × 10−3
2-Butanol 2.43 × 10−3 2.98 × 10−3 3.94 × 10−3 5.07 × 10−3 6.55 × 10−3
DMSO 2.56 × 10-3 3.15 × 10−3 4.09 × 10−3 5.34 × 10−3 6.59 × 10−3
1-Butanol 2.89 × 10−3 3.46 × 10−3 4.32 × 10−3 5.36 × 10−3 6.84 × 10−3
Ethanol 3.82 × 10−3 4.54 × 10−3 5.31 × 10−3 6.29 × 10−3 7.76 × 10−3
IPA 3.95 × 10−3 4.64 × 10−3 5.58 × 10−3 6.76 × 10−3 8.19 × 10−3
Water 8.02 × 10−3 8.66 × 10−3 9.45 × 10−3 1.03 × 10−2 1.13 × 10−2
Methanol 1.08 × 10−2 1.17 × 10−2 1.26 × 10−2 1.38 × 10−2 1.49 × 10−2
PG 3.18 × 10−2 3.27 × 10−2 3.47 × 10−2 3.67 × 10−2 3.90 × 10−2
THP 3.20 × 10−2 3.45 × 10−2 3.81 × 10−2 4.10 × 10−2 4.65 × 10−2
EG 4.66 × 10−2 4.87 × 10−2 5.12 × 10−2 5.39 × 10−2 5.72 × 10−2
PEG-400 1.09 × 10−1 1.15 × 10−1 1.23 × 10−1 1.32 × 10−1 1.41 × 10−1
xidl 3.74 × 10−2 4.35 × 10−2 5.05 × 10−2 5.85 × 10−2 6.76 × 10−2

a The relative uncertainties ur are ur(T) = 0.013, ur(p) = 0.003 and ur(xe) = 0.014.