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. 2021 Feb 1;26(3):752. doi: 10.3390/molecules26030752

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Formation and metabolization of sulforaphane. Sulforaphane (SFN) is formed by the hydrolysis of glucoraphanin catalyzed by either plant or bacterial myrosinase. After intake, SFN is metabolized through the mercapturic acid pathway. Initially, isothiocyanates are conjugated with glutathione (GSH) in a glutathione transferase (GST)-catalyzed reaction. Then, successive cleavage reactions catalyzed by γ-glutamyltranspeptidase, cysteinylglycinase, and N-acetyltransferase occur to generate sulforaphane-N-acetylcysteine (SFR-NAC) [8].