Table 4.

Factors associated with risk of death in GBC patients stratified by AJCC 8th T-stage classification.

Factors	Variable	T1		T2		T3		T4
		HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
Age	<55 years	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	55–69 years	1.327	[0.861,2.044]	1.163	[0.967,1.398]	1.034	[0.888,1.203]	0.955	[0.598,1.525]
	70 and over	2.647	[1.740,4.025]	1.486	[1.235,1.787]	1.141	[0.974,1.337]	1.269	[0.766,2.101]
Sex	Male	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	Female	0.748	[0.609,0.919]	0.934	[0.846,1.031]	0.960	[0.872,1.058]	0.817	[0.577,1.157]
Race	White	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	Black	0.98	[0.733,1.311]	1.161	[1.018,1.324]	1.104	[0.965,1.263]	0.997	[0.628,1.584]
	Other	1.079	[0.704,1.652]	0.796	[0.663,0.956]	0.877	[0.639,0.927]	1.153	[0.658,2.019]
Charlson–Deyo	0	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	1	0.995	[0.788,1.256]	1.149	[1.035,1.275]	1.136	[1.024,1.261]	0.965	[0.661,1.409]
	2+	1.510	[1.129,2.020]	1.573	[1.366,1.812]	1.126	[0.950,1.335]	0.691	[0.340,1.404]
Insurance	Private insurance	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	Medicare/public, or uninsured	1.288	[0.966,1.717]	1.154	[1.027,1.296]	1.138	[1.018,1.272]	1.260	[0.895,1.772]
Center Volume	5 or fewer cases/ 3 y period	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	>5 cases/ 3 y period	0.937	[0.738,1.188]	0.890	[0.801,0.988]	0.963	[0.871,1.065]	0.745	[0.538,1.031]
Facility	Community	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	Comprehensive community	0.848	[0.614,1.171]	0.905	[0.772,1.060]	0.997	[0.843,1.179]	1.347	[0.674,2.695]
	Academic	0.780	[0.557,1.090]	0.792	[0.672,0.933]	0.760	[0.641,0.902]	1.132	[0.553,2.315]
Year of diagnosis	2004–2006	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	2007–2009	0.954	[0.707,1.286]	1.061	[0.905,1.243]	1.007	[0.922,1.152]	1.639	[1.039,2.586]
	2010–2012	0.750	[0.572,0.982]	0.783	[0.678,0.904]	0.760	[0.661,0.873]	1.493	[0.939,2.374]
	2013–2015	0.489	[0.364,0.657]	0.745	[0.645,0.861]	0.728	[0.634,0.836]	1.044	[0.636,1.713]
Surgery	Simple resection	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	Radical resection	0.923	[0.728,1.172]	0.957	[0.855,1.070]	0.915	[0.816,1.026]	0.836	[0.554,1.261]
Chemotherapy	No	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	Yes	1.043	[0.693,1.569]	1.003	[0.894,1.127]	0.69	[0.622,0.764]	0.637	[0.446,0.910]
Radiation	No	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	Yes	0.832	[0.503,1.377]	0.638	[0.553,0.735]	0.619	[0.546,0.702]	0.515	[0.337,0.787]
Grade	Well- differentiated	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	Moderate/ intermediate differentiation	1.218	[0.951,1.560]	1.535	[1.313,1.795]	1.176	[0.970,1.426]	1.610	[0.807,3.212]
	Poorly differentiated or undifferentiated	1.968	[1.460,2.654]	2.434	[2.080,2.849]	1.765	[1.460,2.133]	1.822	[0.926,3.583]
	N/A, unknown, high-grade dysplasia	1.264	[0.909,1.757]	1.730	[1.348,2.221]	1.550	[1.202,2.000]	1.504	[0.670,3.380]
N stage	N0	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]	1	[1.000,1.000]
	N1	2.416	[1.683,3.467]	1.74	[1.554,1.947]	1.450	[1.304,1.612]	1.095	[0.729,1.645]
	N2	2.243	[0.665,7.566]	1.775	[1.331,2.369]	1.527	[1.228,1.898]	1.693	[0.949,3.021]
	Nx	1.256	[0.978,1.612]	2.097	[1.866,2.356]	2.010	[1.777,2.274]	1.100	[0.680,1.780]