Table 5.
Factors associated with risk of death in GBC patients with stage ≥ IIIB.
| Factors | Variable | AJCC 7th Edition | AJCC 8th Edition | ||
|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | ||
| Stage | Stage IIIB | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| Stage IVA | 1.968 | [1.638,2.365] | 1.688 | [1.481,1.923] | |
| Stage IVB | 2.379 | [2.120,2.670] | 2.008 | [1.878,2.148] | |
| Age | <55 years | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| 55–69 years | 0.994 | [0.867,1.139] | 0.982 | [0.857,1.126] | |
| 70 and over | 1.139 | [0.986,1.316] | 1.111 | [0.963,1.283] | |
| Sex | Male | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| Female | 0.899 | [0.821,0.985] | 0.917 | [0.838,1.003] | |
| Race | White | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| Black | 0.997 | [0.885,1.123] | 1.005 | [0.893,1.131] | |
| Other | 0.862 | [0.734,1.013] | 0.856 | [0.729,1.005] | |
| Charlson–Deyo | 0 | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| 1 | 1.07 | [0.974,1.176] | 1.065 | [0.970,1.170] | |
| 2+ | 1.347 | [1.159,1.566] | 1.313 | [1.131,1.524] | |
| Insurance | Private insurance | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| Medicare/public, or uninsured | 1.098 | [0.996,1.211] | 1.093 | [0.992,1.205] | |
| Facility type | Community | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| Comprehensive community | 0.974 | [0.837,1.134] | 0.996 | [0.856,1.158] | |
| Academic | 0.759 | [0.650,0.886] | 0.768 | [0.658,0.897] | |
| Center Volume | 5 or fewer cases/3 y period | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| >5 cases/3 y period | 0.932 | [0.851,1.021] | 0.919 | [0.840,1.007] | |
| Year of diagnosis | 2004–2006 | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| 2007–2009 | 1.008 | [0.883,1.150] | 1.009 | [0.884,1.152] | |
| 2010–2012 | 0.956 | [0.842,1.085] | 0.949 | [0.836,1.076] | |
| 2013–2015 | 0.882 | [0.776,1.003] | 0.869 | [0.766,0.986] | |
| Surgery | Simple resection | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| Radical resection | 0.938 | [0.846,1.040] | 0.931 | [0.840,1.032] | |
| Chemotherapy | No | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| Yes | 0.579 | [0.529,0.634] | 0.57 | [0.521,0.624] | |
| Radiotherapy | No | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| Yes | 0.756 | [0.676,0.846] | 0.74 | [0.661,0.827] | |
| Grade | Well-differentiated | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| Moderate/intermediate differentiation | 1.43 | [1.194,1.712] | 1.446 | [1.210,1.727] | |
| Poorly differentiated or undifferentiated | 1.953 | [1.636,2.332] | 1.958 | [1.644,2.334] | |
| N/A, unknown, high-grade dysplasia | 1.54 | [1.216,1.949] | 1.498 | [1.185,1.894] | |
| Nodal disease | N0 | 1 | [1.000,1.000] | 1 | [1.000,1.000] |
| N1 | 1.224 | [1.067,1.404] | 1.139 | [0.995,1.304] | |
| N2 | 0.853 | [0.682,1.066] | 0.861 | [0.713,1.039] | |
| NX | 1.578 | [1.371,1.816] | 1.535 | [1.336,1.764] |