Table 1.

Studies evaluating effects of ADM on cardiovascular system.

Author	Population	Organ	Effect
Lippton (1994) [14]	rat	pulmonary vascular	decreased lobar arterial pressure highest doses mildly decreased systemic arterial pressure
Lainchbury (1997) [15]	human	vascular	reduced mean arterial pressure reduced systolic arterial pressure reduced diastolic arterial pressure
Parkes (1997) [16]	sheep	vascular, heart	vasodilation increased cardiac contractility and cardiac output hypotensive actions
Ikenouchi (1997) [17]	rabbit	cardiomyocytes	negative inotropic effect
Yoshimoto (1998) [18]	rat, pig	rat aorta, pig coronary artery	vasodilation
Sait (1998) [19]	rat	brain ventricular	induced hypertension, tachycardia central regulation of the cardiovascular system
Szokodi (1998) [20]	rat	heart	enhanced cardiac contractility
Ihara (2000) [21]	rat	papillary muscles	positive inotropic effects increased intracellular contents of cAMP
Saetrum Opgaard (2000) [22]	human	cardiomyocytes	no positive or negative inotropic actions