Table 3.
State occupancy probability and mean sojourn time resulting from the G-computation.
| With Corticosteroids and Tocilizumab/Anakinra | Without Corticosteroids and Tocilizumab/Anakinra | With Corticosteroids and without Tocilizumab/Anakinra | Without Corticosteroids and with Tocilizumab/Anakinra | |||||
|---|---|---|---|---|---|---|---|---|
| State Occupation Probability (95% CI) |
Mean Sojourn in Days (95% CI) | State Occupation Probability (95% CI) |
Mean Sojourn in Days (95% CI) | State Occupation Probability (95% CI) |
Mean Sojourn in Days (95% CI) | State Occupation Probability (95% CI) |
Mean Sojourn in Days (95% CI) | |
| Day 10 | ||||||||
| Hospital discharge | 13.6 (11, 17.4) | 0.5 (0.1, 0.6) | 12.3 (10.2, 15.7) | 0.5 (0.4, 0.6) | 13.5 (10.9, 17.2) | 0.5 (0.4, 0.7) | 12.4 (10.3, 15.8) | 0.5 (0.4, 0.6) |
| ICU discharge | 27 (21.8, 32.5) | 1.4 (0.6, 1.8) | 22.5 (19.2, 26.1) | 1.2 (1, 1.5) | 26.2 (21.4, 31.3) | 1.4 (1.1, 1.7) | 23.5 (19.8, 27.5) | 1.2 (1, 1.6) |
| ICU non-invasive | 11 (6.6, 15.2) | 3.2 (2.7, 4.8) | 7.8 (5, 10.7) | 2.8 (2.4, 3.1) | 9.4 (5.8, 13.5) | 3.2 (2.7, 3.6) | 9.7 (6.1, 13.5) | 2.9 (2.5, 3.2) |
| ICU invasive | 31.2 (22, 36.6) | 3.8 (3.2, 4.3) | 39.5 (31.6, 43.4) | 4.5 (3.9, 4.8) | 33.7 (25.3, 38.8) | 3.9 (3.3, 4.4) | 36.6 (27.8, 41.8) | 4.4 (3.8, 4.8) |
| ECMO | 5.7 (4.1, 11.1) | 0.6 (0.5, 0.8) | 6 (4.2, 12.2) | 0.6 (0.5, 0.9) | 5.7 (4.2, 11.2) | 0.6 (0.5, 0.9) | 5.9 (4.2, 12.1) | 0.6 (0.5, 0.9) |
| Death | 11.5 (9.1, 15.4) | 0.5 (0.1, 0.7) | 11.9 (9.6, 15.5) | 0.5 (0.4, 0.7) | 11.6 (9.2, 15.5) | 0.5 (0.4, 0.7) | 11.8 (9.6, 15.5) | 0.5 (0.4, 0.7) |
| Day 28 | ||||||||
| Hospital discharge | 52.2 (44.3, 60.5) | 7.3 (2.8, 8.6) | 45 (39.4, 51.1) | 6.4 (5.5, 7.6) | 48.9 (42.5, 55.5) | 7 (6, 8.3) | 48.8 (41.8, 57.3) | 6.8 (5.8, 8) |
| ICU discharge | 13.5 (9.3, 18.4) | 4.8 (3.8, 5.8) | 11.6 (8.1, 15.8) | 4 (3.4, 4.8) | 11.8 (8.1, 16.2) | 4.4 (3.7, 5.4) | 13.5 (9.3, 18.4) | 4.4 (3.6, 5.4) |
| ICU non-invasive | 1.7 (0.7, 2.8) | 4.2 (3.4, 7.1) | 1.3 (0.7, 2.1) | 3.5 (2.9, 4.1) | 1.3 (0.7, 2.2) | 3.9 (3.3, 4.7) | 1.7 (0.7, 2.7) | 3.9 (3.1, 4.6) |
| ICU invasive | 6.5 (3.5, 10) | 6.5 (5, 9.6) | 11.3 (8, 14) | 8.4 (7, 9.4) | 9.6 (6.5, 12.2) | 7.3 (5.7, 8.3) | 7.8 (4.5, 12.3) | 7.6 (6.1, 8.9) |
| ECMO | 1.5 (0.4, 5.2) | 1.1 (0.8, 2.2) | 2 (0.6, 6.4) | 1.2 (0.8, 2.4) | 1.8 (0.6, 5.8) | 1.1 (0.8, 2.3) | 1.6 (0.5, 5.6) | 1.1 (0.8, 2.3) |
| Death | 24.6 (19.4, 30.4) | 4 (1.9, 5.1) | 28.8 (23.4, 34.1) | 4.4 (3.6, 5.5) | 26.6 (21.7, 31.7) | 4.2 (3.4, 5.2) | 26.6 (21.1, 32.2) | 4.2 (3.4, 5.3) |
| Day 60 | ||||||||
| Hospital discharge | 68.4 (60.9, 75.1) | 27.5 (17.1, 31.2) | 60.9 (54.1, 67.3) | 24.1 (21.1, 27) | 64.2 (57.5, 69.9) | 25.8 (22.8, 28.7) | 65.7 (58.1, 73.4) | 26 (22.6, 29.9) |
| ICU discharge | 3.2 (1.6, 5.5) | 6.7 (5.1, 9.8) | 3.4 (1.8, 5.8) | 5.9 (4.6, 7.6) | 3.2 (1.7, 5.6) | 6.3 (4.9, 8.1) | 3.4 (1.7, 5.8) | 6.4 (4.9, 8.3) |
| ICU non-invasive | 0.3 (0.1, 0.6) | 4.6 (3.7, 8.3) | 0.3 (0.1, 0.6) | 3.9 (3.2, 4.6) | 0.3 (0.1, 0.6) | 4.3 (3.5, 5.1) | 0.3 (0.1, 0.6) | 4.2 (3.3, 5) |
| ICU invasive | 0.6 (0.2, 1.4) | 7.4 (5.5, 13) | 1.7 (1.1, 2.6) | 10.1 (8.3, 11.4) | 1.5 (1, 2.2) | 8.7 (6.8, 10) | 0.7 (0.2, 1.7) | 8.6 (6.8, 10.6) |
| ECMO | 0.2 (0, 1.7) | 1.3 (0.8, 3.2) | 0.3 (0, 2) | 1.5 (0.9, 3.6) | 0.3 (0, 1.8) | 1.4 (0.9, 3.3) | 0.2 (0, 1.8) | 1.4 (0.8, 3.3) |
| Death | 27.3 (21.2, 33.8) | 12.5 (8.6, 15.4) | 33.4 (27.1, 39.3) | 14.6 (11.9, 17.4) | 30.6 (25, 36.1) | 13.5 (11.1, 16.2) | 29.7 (23.1, 36.2) | 13.4 (10.6, 16.4) |
Legend. ICU: intensive care unit. ECMO: extracorporeal membrane oxygenation. ICU non-invasive: in ICU without mechanical ventilation. ICU invasive: in ICU with mechanical ventilation. CI: confidence interval. Mean sojourn time: mean number of days spent in each state.