Table 1.

Time (h) to reach 50% cell death in medium containing 10 mmol/L of sodium L-lactate, no glucose, no glutamine and 1% FBS ± AZD3965.

[AZD3965], 1 dose, 72 h
	Vehicle	1 nmol/L	10 nmol/L	100 nmol/L	1 µmol/L	10 µmol/L	n
T47D	No cell death 1	No cell death	No cell death	No cell death	No cell death	No cell death	15–16
MCF7	No cell death	No cell death	No cell death	No cell death	No cell death	No cell death	15–16
MCF10A	194 ± 20	152 ± 15	171 ± 19	241 ± 45	165 ± 21	222 ± 26	15–16
BJ fibro	460 ± 96	299 ± 34	396 ± 130	283 ± 25	No cell death	141 ±36	15–16
[AZD3965], 3 daily doses, 72 h
	Vehicle	1 nmol/L	10 nmol/L	100 nmol/L	1 µmol/L	10 µmol/L	n
T47D	181 ± 31	No cell death	No cell death	No cell death	187 ± 42	138 ±51	15–16
MCF7	103 ± 15	No cell death	138 ± 25	153 ± 30	68 ± 35	106 ± 8	15–16
MCF10A	119 ± 13	120 ± 14	109 ± 11	88 ± 7	104 ± 10	95 ± 7	16
BJ fibro	73 ± 3	82 ± 7	66 ± 4	68 ± 6	63 ± 2	59 ± 1	15–16

¹ Significant cell death was determined with a one-sample t test compared to steady state. Effects of AZD3965 compared to vehicle were tested using one-way ANOVA with Dunnett’s post-hoc test. All p-values are >0.05.