Table 2.

Cell doubling times (h) in medium containing 25 mmol/L glucose, 10 mmol/L GlutaMAX and 10% FBS ± AZD3965.

[AZD3965], 1 dose, 72 h
	Vehicle	1 nmol/L	10 nmol/L	100 nmol/L	1 µmol/L	10 µmol/L	n
T47D	78 ± 3	77 ± 3	71 ± 4	75 ± 5	74 ± 4	103 ± 5 ***	8
MCF7	62 ± 3	58 ± 2	57 ± 1	64 ± 1	62 ± 2	72 ± 3 *	7–8
MCF10A	70 ± 3	60 ± 1	63 ± 2	72 ± 6	57 ± 2 *	63 ± 3	8
BJ fibroblasts	50 ± 1	49 ± 1	47 ± 1	46 ± 1 *	47 ± 1	48 ± 1	8
[AZD3965], 3 daily doses, 72 h
	Vehicle	1 nmol/L	10 nmol/L	100 nmol/L	1 µmol/L	10 µmol/L	n
T47D	49 ± 5	52 ± 6	52 ± 2	53 ± 3	51 ± 4	59 ± 7	7–8
MCF7	87 ± 6	98 ± 11	86 ± 4	100 ± 4	88 ± 4	129 ± 4 **	7–8
MCF10A	132 ± 15	127 ± 16	91 ± 3	164 ± 24	108 ± 8	123 ± 13	7–8
BJ fibroblasts	53 ± 1	54 ± 1	51 ± 0.5	52 ± 0.5	53 ± 0.5	55 ± 1	7–8

* p < 0.05, ** p < 0.01, *** p < 0.005 compared to vehicle; by one-way ANOVA with Dunnett’s post-hoc test.