Table 2.
Three verified alcohol–single nucleotide polymorphism (SNP) interactions associated with prostate cancer aggressiveness.
| Alcohol-SNP Interaction | Combined | Discovery | Validation | |||
|---|---|---|---|---|---|---|
| p-Value 1 | Mode 2 | p-Value 1 | Mode 2 | p-Value 1 | Mode 2 | |
| Heavy alcohol Intake–rs13107662 (CAMK2D) | 6.2 × 10−6 | Add | 2.1 × 10−4 | Add | 0.003 | Rec 4 |
| Heavy beer Intake–rs9907521 (PRKCA) | 7.1 × 10−5 | Add | 0.005 | Add | 0.005 | Add |
| Heavy beer Intake–rs11925452 (ROBO1) | 8.2 × 10−4 | Add | 0.003 | Rec 3 | 0.002 | Add |
1p-value of alcohol–SNP interactions were based on logistic regression adjusted for study site, first six principal components, and smoking status. 2 Add: additive, Rec: recessive mode; 3 p = 0.073 for the additive mode; 4 p = 0.006 for the additive mode.