Table 3.
SNP individual effects for SNPs involved with alcohol–SNP interactions associated with prostate cancer (PCa) aggressiveness.
| KERRYPNX | Combine PCa Aggressiveness (17.7%) |
Discovery PCa Aggressiveness (17.5%) |
Validation PCa Aggressiveness (17.9%) |
||||
|---|---|---|---|---|---|---|---|
| SNP (Gene, Major > Minor Allele, MAF) 1 | Total N (%) |
Yes N (%) |
No N (%) |
Yes N (%) |
No N (%) |
Yes N (%) |
No N (%) |
| rs13107662 (CAMK2D, A > G, 34.5%) 2 | |||||||
| AA | 657 (43.4) | 130 (19.8) | 527 (80.2) | 74 (21.8) | 266 (78.2) | 56 (17.7) | 261 (82.3) |
| AG | 670 (44.3) | 124 (18.5) | 546 (81.5) | 56 (18.3) | 250 (81.7) | 68 (18.7) | 296 (81.3) |
| GG | 187 (12.4) | 56 (30.0) | 131 (70.1) | 30 (30.3) | 69 (69.7) | 26 (29.6) | 62 (70.5) |
| p = 0.003 | p = 0.046 | p = 0.046 | |||||
| rs9907521 (PRKCA, A > G, 7.0%) 2 | |||||||
| AA | 1824 (86.5) | 362 (19.9) | 1462 (80.2) | 172 (19.1) | 727 (80.9) | 190 (20.5) | 735 (79.5) |
| AG | 273 (13.0) | 51 (18.7) | 222 (81.3) | 27 (21.1) | 101 (78.9) | 24 (16.6) | 121 (83.5) |
| GG | 11 (0.5) | 3 (27.3) | 8 (72.7) | 3 (33.3) | 6 (66.7) | 0 | 2 (100) |
| p = 0.640 | p = 0.456 | p = 0.561 | |||||
| rs11925452 (ROBO1, G > A, 21.1%) 2 | |||||||
| GG | 1312 (62.1) | 267 (20.4) | 1045 (79.7) | 130 (20.4) | 507 (79.6) | 137 (20.3) | 538 (79.7) |
| AG | 710 (33.6) | 130 (18.3) | 580 (81.7) | 61 (17.1) | 295 (82.9) | 69 (19.5) | 285 (80.5) |
| AA | 90 ( 4.3) | 19 (21.1) | 71 (78.9) | 11 (25.0) | 33 (75.0) | 9 (17.4) | 38 (82.6) |
| AA | |||||||
| AA | |||||||
| AA | |||||||
| p = 0.514 | p = 0.274 | p = 0.889 | |||||
1 MAF: minor allele frequency. 2 p-values were based on Fisher’s exact test.