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. 2021 Feb 2;22(3):1493. doi: 10.3390/ijms22031493

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Illustration of the findings from the study. The study revealed that vasoactive and potentially proliferative acting mediators were released by the nonadherent HUVEC over time. There was no evidence for an inflammatory activation of HUVEC solely by cultivation under nonadherent conditions. Further studies will clarify whether mediators released and/or cell remnants from the apoptosis process can influence the surrounding environment and perhaps the endothelialization capacity of potential implant materials during in vitro static and dynamic testing (Picture modified from Servier Medical Art; Licence: CC BY 3.0; https://smart.servier.com/).