Table 1.
Micellar DDS based on drug/biopolymer conjugates.
| Biopolymer | Conjugated Drug | Micellar Size (nm) |
ZP Value (mV) |
Preparation Method |
Reference |
|---|---|---|---|---|---|
| N-octyl-N arginine chitosan (+) | Insulin (−) | 257 ÷ 327 | 4.61 ÷ 6.53 | Ionic complexation | [16] |
| Adipic dihydrazole hyaluronic acid | Quercetin | 172.1 | −20.3 | Direct dissolution | [17] |
| Hyaluronic acid | Curcumin | 84 ÷ 131 | −19.43 ÷ 24.27 | Sonication | [18] |
| Hyaluronic acid | Curcumin | 209 ÷ 926 | −25 ÷ −35 | Direct dissolution | [19] |
| Dithiodipropionic acid hyaluronic acid | Quercetin + Curcumin | 172.6 | −33.71 | Dialysis | [20] |
| Heparin-graft-deocycholate | Doxorubicin | 154.7 166.0 |
−32.7 −36.7 |
Sonication | [21] |
| Pegylated heparin | Pyropheophorbide-a | 97.31 | −14.63 | Not indicated | [22] |
| Alginate | Curcumin | 459 | −45 | Direct dissolution | [23] |
| Galactosylated alginate | Curcumin | 235 | −29 | Direct dissolution | [24] |
| Alginate | Curcumin | 200 | −53 | Direct dissolution | [25,26] |
| Dextran | Curcumin | 222 | −15.2 | Direct dissolution | [27] |
| Dextran | Indomethacin | 68.3 | n.d. | Dialysis | [28] |
| Dextran | Indomethacin | 200 | −1.8 | Dialysis | [29] |
| Hydroxyethyl starch | Curcumin | <100 | −27.8 | Precipitation/dialysis | [30] |
| Fructose | Curcumin | 100 ÷ 150 | - | Solution mixing | [31] |
| Bovine serum albumin functionalized poly(oligo (ethylene glycol) methyl ether methacrylate) | Sprouty 1 (C-12) (Spry1) protein | 15 ÷ 25 | −9 ÷ 2 | Direct dissolution | [32] |
| Human serum albumin | Adriamycin | 100 | 5 ÷ 10 | Thin film hydration | [33] |
| ABD035 peptide | Paclitaxel | 29 | 8.7 | Dialysis | [34] |
(+)—cation, (−)—anion, n.d.—not determined.