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. 2021 Feb 2;22(3):1501. doi: 10.3390/ijms22031501

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The point graph and heatmap showing the average intensity of proteins creating TNFα/NFκB (A) and IκBKB/HSP90 (B) complexes in keratinocytes following UVA (30 J/cm²) or UVB (60 mJ/cm²) radiation and treated with cannabidiol (CBD, 4 μM) in a three-dimensional culture model. Proteins IDs: O14920, inhibitor of nuclear factor κ-B kinase subunit B; P01375, tumor necrosis factor α; P07900, heat shock protein HSP 90A; P08238, heat shock protein HSP 90B; P19838, nuclear factor NFκB p105; P62888, 60S ribosomal protein L30; Q02878, 60S ribosomal protein L6; Q8N163, cell cycle and apoptosis regulator protein 2. Statistical significances showed only for the whole complexes. X: statistically significant differences vs. non-treated cells, p < 0.05; y: statistically significant differences vs. CBD-treated cells, p < 0.05; a: statistically significant differences vs. UVA-irradiated cells, p < 0.05; b: statistically significant differences vs. UVB-irradiated cells, p < 0.05.