Figure 6.

The suspected mechanism of BGP-15 treatment in a hypertension-induced heart failure model. BGP-15 has a beneficial effect against hypertension-induced cardiac remodelling and cardiac fibrosis. The BGP-15 treatment decreases the activity of TGFβ/Smad and MAPK signalling factors and in this way prevents against hypertension-induced interstitial collagen deposition. BGP-15 favourably influences the prosurvival signalling pathways. Moreover, the mitochondrial biogenesis is activated due to BGP-15 administration, thereby resulting in an increase in mitochondrial mass.