Table 1.
WKY (n = 7) | SHR-baseline (n = 7) | SHR-C (n = 7) | SHR-B (n = 7) | |
---|---|---|---|---|
BWSTART (g) | 386.40 ± 4.33 | 343.21 ± 2.48∗∗ | 346.90 ± 6.65∗∗ | 340.73 ± 6.32∗∗ |
BWEND (g) | 401.45 ± 8.94 | — | 358.13 ± 5.08∗∗ | 356.85 ± 4.54∗∗ |
HWEND (g) | 1.12 ± 0.04 | 1.16 ± 0.02 | 1.49 ± 0.05∗∗,## | 1.23 ± 0.02§§ |
VWEND (g) | 0.95 ± 0.04 | 1.09 ± 0.02 | 1.33 ± 0.05∗∗,## | 1.14 ± 0.02§§ |
VW/BWEND (mg/g) | 2.28 ± 0.11 | 3.19 ± 0.08∗∗ | 3.73 ± 0.16∗∗,## | 3.21 ± 0.03∗,§ |
VW/TLEND (mg/mm) | 21.27 ± 0.79 | 24.76 ± 0.82∗ | 29.79 ± 0.94∗∗,## | 25.76 ± 0.46∗,§§ |
Lung wet weight/weightEND (g/g) | 4.42 ± 0.26 | 4.51 ± 0.13 | 5.68 ± 0.24∗∗,## | 4.68 ± 0.13§§ |
BWSTART: body weight at the beginning of the treatment; BWEND: body weight at the end of the treatment; HWEND: heart weight at the end of the treatment; VWEND: ventricles weight at the end of the treatment; TLEND: length of the right tibia at the end of the treatment. Values are means + SEM. WKY: age-matched normotensive Wistar-Kyoto rats, n = 7; SHR-Baseline: 15-month-old spontaneously hypertensive rats, n = 7; SHR-C: nontreated spontaneously hypertensive rats, n = 7; SHR-B: spontaneously hypertensive rats receiving BGP-15 for 18 weeks, n = 7. ∗p < 0.05 vs. WKY, ∗∗p < 0.01 vs. WKY, ##p < 0.01 vs. SHR-Baseline, §p < 0.05 vs. SHR-C, §§p < 0.01 vs. SHR-C.