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. 2021 Jan 20;41(1):10–19. [Article in Chinese] doi: 10.12122/j.issn.1673-4254.2021.01.02

1.

RES治疗AD靶点

Target proteins of RES againstAD

Number Gene ID Protein description Gene symbol
1 6868 ADAM metallopeptidase domain 17 ADAM17
2 152 Adrenoceptor alpha 2C ADRA2C
3 154 Adrenoceptor beta 2 ADRB2
4 196 Aryl hydrocarbon receptor AHR
5 351 Amyloid beta precursor protein APP
6 775 Calcium voltage-gated channel subunit alpha1 C CACNA1C
7 776 Calcium voltage-gated channel subunit alpha1 D CACNA1D
8 983 Cyclin dependent kinase 1 CDK1
9 1020 Cyclin dependent kinase 5 CDK5
10 1139 Cholinergic receptor nicotinic alpha 7 subunit CHRNA7
11 2099 Estrogen receptor 1 ESR1
12 2100 Estrogen receptor 2 ESR2
13 2263 Fibroblast growth factor receptor 2 FGFR2
14 2931 Glycogen synthase kinase 3 alpha GSK3A
15 2932 Glycogen synthase kinase 3 beta GSK3B
16 3480 Insulin like growth factor 1 receptor IGF1R
17 3630 Insulin INS
18 3643 Insulin receptor INSR
19 3815 KIT proto-oncogene, Receptor tyrosine kinase KIT
20 3932 LCK proto-oncogene, Src family tyrosine kinase LCK
21 4128 Monoamine oxidase A MAOA
22 4137 Microtubule associated protein tau MAPT
23 4311 Membrane metalloendopeptidase MME
24 4312 Matrix metallopeptidase 1 MMP1
25 4313 Matrix metallopeptidase 2 MMP2
26 4318 Matrix metallopeptidase 9 MMP9
27 4842 Nitric oxide synthase 1 NOS1
28 4835 N-ribosyldihydronicotinamide:quinone reductase 2 NQO2
29 5144 Phosphodiesterase 4D PDE4D
30 6532 Solute carrier family 6 member 4 SLC6A4
31 7040 Transforming growth factor beta 1 TGFB1
32 7276 Transthyretin TTR
33 7345 Ubiquitin C-terminal hydrolase L1 UCHL1
34 7415 Valosin containing protein VCP
35 7421 Vitamin D receptor VDR
36 7465 WEE1 G2 checkpoint kinase WEE1