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. 2020 Oct 19;185(2):293–305. doi: 10.1007/s10549-020-05955-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Differential gene expression and pathway analysis. a Overlapping differentially expressed genes associated with high ISG15 mRNA expression. Cases depicting (I) overexpressed differentially expressed genes associated with high ISG15 mRNA on both METABRIC and TCGA restricted on Luminal B and HER2-positive cohorts. (II) Overlapping downregulated differentially expressed genes associated with High ISG15 mRNA on both METABRIC and TCGA restricted on Luminal B and HER2-positive cohorts. DGE: differentially expressed gene, (↓): downregulated genes, (↑) overexpressed genes. b The enriched biological process generated by the common 490 overexpressed genes based on high ISG15 mRNA expression on both METABRIC and TCGA restricted on Luminal B and HER2-positive cohorts