Table 2.
Potential NOAC drug interactions with drugs with a frequency of ≥ 50 for at least one NOAC at index, in 244,597 patients with newly initiated NOAC treatment during 2008–2017 in Swedish outpatient care. Values are given as n (%)
| Apixaban | Rivaroxaban | Dabigatran | Edoxaban | |
|---|---|---|---|---|
| n = 148,108 | n = 59,276 | n = 35,617 | n = 1596 | |
| Cardiovascular drugs | ||||
| Amiodarone | 1368 (0.92) | 341 (0.58) | 207 (0.58) | 38 (2.38) |
| Diltiazem | 528 (0.36) | 259 (0.44) | 195 (0.55) | 9 (0.56) |
| Dronedarone | 1135 (0.77) | 168 (0.28) | 201 (0.56) | 129 (8.08) |
| Verapamil | 962 (0.65) | 416 (0.7) | 250 (0.7) | 16 (1) |
| Antiepileptics | ||||
| Carbamazepine | 525 (0.35) | 159 (0.27) | 113 (0.32) | 19 (1.19) |
| Levetiracetam | 651 (0.44) | 248 (0.42) | 157 (0.44) | 8 (0.5) |
| Phenytoin | 118 (0.08) | 47 (0.08) | 26 (0.07) | 4 (0.25) |
| Valproic acid | 365 (0.25) | 137 (0.23) | 61 (0.17) | 3 (0.19) |
| Antibiotics | ||||
| Clarithromycin | 53 (0.04) | 19 (0.03) | 7 (0.02) | 1 (0.06) |
| Rifampicin | 56 (0.04) | 24 (0.04) | 12 (0.03) | 5 (0.31) |
| Antidepressants | ||||
| Citalopram | 5401 (3.65) | 1930 (3.26) | 1095 (3.07) | 53 (3.32) |
| Escitalopram | 1523 (1.03) | 597 (1.01) | 282 (0.79) | 17 (1.07) |
| Fluoxetine | 438 (0.3) | 208 (0.35) | 115 (0.32) | 3 (0.19) |
| Paroxetine | 473 (0.32) | 208 (0.35) | 120 (0.34) | 7 (0.44) |
| Sertraline | 3498 (2.36) | 1392 (2.35) | 674 (1.89) | 24 (1.5) |
| Clomipramine | 180 (0.12) | 70 (0.12) | 39 (0.11) | 5 (0.31) |
| Duloxetine | 653 (0.44) | 282 (0.48) | 172 (0.48) | 12 (0.75) |
| Venlafaxine | 1212 (0.82) | 517 (0.87) | 264 (0.74) | 19 (1.19) |
| Antimycotics | ||||
| Fluconazole | 159 (0.11) | 78 (0.13) | 21 (0.06) | 5 (0.31) |
| Antineoplastic agents | ||||
| Enzalutamide | 50 (0.03) | 7 (0.01) | 10 (0.03) | 3 (0.19) |
| Bicalutamide | 1033 (0.7) | 352 (0.59) | 150 (0.42) | 13 (0.81) |
| Tamoxifen | 390 (0.26) | 192 (0.32) | 87 (0.24) | 11 (0.69) |
| Immunomodulating agents | ||||
| Ciclosporin | 76 (0.05) | 14 (0.02) | 4 (0.01) | 2 (0.13) |
| Dexamethasone | 205 (0.14) | 49 (0.08) | 5 (0.01) | 3 (0.19) |
| Prednisone | 162 (0.11) | 90 (0.15) | 19 (0.05) | 2 (0.13) |
| Tacrolimus | 174 (0.12) | 42 (0.07) | 7 (0.02) | 5 (0.31) |
| Analgesic | ||||
| Tramadol | 1520 (1.03) | 1351 (2.28) | 2428 (6.82) | 11 (0.69) |
| Antithombotic agents | ||||
| Acetylsalicylic acid | 39,888 (26.93) | 14,168 (23.9) | 8541 (23.98) | 375 (23.5) |
| Clopidogrel | 7060 (4.77) | 2380 (4.02) | 1191 (3.34) | 69 (4.32) |
| Dipyridamole | 808 (0.55) | 211 (0.36) | 207 (0.58) | 2 (0.13) |
| Ticagrelor | 1202 (0.81) | 365 (0.62) | 207 (0.58) | 17 (1.07) |
| Dalteparin | 3495 (2.36) | 1912 (3.23) | 535 (1.5) | 145 (9.09) |
| Enoxaparin | 571 (0.39) | 236 (0.4) | 116 (0.33) | 16 (1) |
| Tinzaparin | 2488 (1.68) | 1026 (1.73) | 279 (0.78) | 86 (5.39) |
| NSAIDs | ||||
| Celecoxib | 1105 (0.75) | 154 (0.26) | 134 (0.38) | 6 (0.38) |
| Dexibuprofen | 120 (0.08) | 80 (0.13) | 63 (0.18) | 1 (0.06) |
| Diclofenac | 2038 (1.38) | 1622 (2.74) | 1818 (5.1) | 7 (0.44) |
| Etoricoxib | 4207 (2.84) | 2845 (4.8) | 782 (2.2) | 6 (0.38) |
| Ibuprofen | 1256 (0.85) | 666 (1.12) | 559 (1.57) | 9 (0.56) |
| Ketoprofen | 781 (0.53) | 424 (0.72) | 420 (1.18) | 4 (0.25) |
| Meloxicam | 59 (0.04) | 29 (0.05) | 30 (0.08) | 0 (0) |
| Nabumetone | 242 (0.16) | 87 (0.15) | 308 (0.86) | 1 (0.06) |
| Naproxen | 3604 (2.43) | 1990 (3.36) | 1098 (3.08) | 19 (1.19) |
| Tenoxicam | 53 (0.04) | 30 (0.05) | 26 (0.07) | 0 (0) |
Percentages based on the total number of patients dispensed each NOAC. The full table is available in Online Resource, Suppl. Table 4