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. 2020 Apr 13;78(1):351–372. doi: 10.1007/s00018-020-03510-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — CMT2B peripheral sensory neurons show inhibited neurite outgrowth. a Control iPS cells were differentiated in peripheral sensory neurons and analyzed by immunohistochemistry at 17 days of differentiation for Brn3a, Neurofilaments, Peripherin and CGRP. Bars 50 µm. b Phase contrast images of iPSCs-derived sensory neurons from control (CTRL) and CMT2B patients carrying the RAB7^V162M mutation (#2 and #3) 6 days after plating. The IncuCyte automated acquisition and analysis show the extension of neurites growth (pink). Neuron cell body clusters are marked in yellow. Bar 200 µm. Automated quantification of neurite length for a time window of 6 days after plating. Neurite length data were collected in units of mm of total neurites detected/mm² and all data are expressed relative to the respective day 0 of plating. Each group is represented by as mean ± SEM (n = 32 image)