Table 1.

Search terms used for database searches, based on the PICO System for search strategy development

Patient/population/problem	Intervention	Comparison/Control	Outcome
Mice Mouse Rodent* Animal Animal model[MH] OR Healthy adult* Young adult* Adult* Cardiovascular disease[MH] CVD TIIDM OR T2DM Diabet* Overweight Obese Elder* Old* adj3 adult* Aging	Red wine polyphenol RWP Resveratrol Pterostilbene[MH] *stilbene	Placebo Control Negative control (Polyphenol adj3 free adj3 control)	*Vascular function *Vascular responsiveness *Vascular reactivity Blood pressure (OR BP) Transcranial doppler (TCD) Flow mediated dilation (FMD) fMRI Blood flow Peripheral blood flow Cerebrovascular blood flow