Table 3.
Median differences (95% CI) of C-IMT progression in relation to alcohol consumption categories
| IMT progression | Abstainers (0 g/d) | Very low (> 0 − 5 g/d) | Low (> 5–10 g/d) | Moderate (> 10 − 30 g/d)a | High (> 30 g/d)b | ||
|---|---|---|---|---|---|---|---|
| Models | n = 1,471 | n = 209 | n = 332 | n = 658 | n = 592 | ||
| β1 (95%CI) | Ref | β1 (95%CI) | β1 (95%CI) | β1 (95%CI) | |||
| IMTmeanm10 | |||||||
| p50 | Model 1 | − 0.004 (− 0.009; 0.001) | – | − 0.009 (− 0.016; − 0.003) | − 0.008 (− 0.013; − 0.002) | − 0.008 (− 0.014; − 0.002) | |
| Model 2 | − 0.005 (− 0.001; − 0.000) | – | − 0.007 (− 0.013; − 0.001) | − 0.006 (− 0.011; − 0.000) | − 0.008 (− 0.014; − 0.002) | ||
| IMTmaxm2 | |||||||
| p50 | Model 1 | 0.004 (− 0.011; 0.019) | – | − 0.010 (− 0.028; 0.008) | 0.000 (− 0.016; 0.016) | − 0.001 (− 0.018; 0.015) | |
| Model 2 | 0.007 (− 0.011; 0.025) | – | − 0.001 (− 0.022; 0.020) | 0.011 (− 0.008; 0.030) | 0.002 (− 0.018; 0.022) | ||
| CC–IMTmeanm2 | |||||||
| p50 | Model 1 | 0.000 (− 0.004; 0.004) | – | − 0.003 (− 0.007; 0.002) | − 0.003 (− 0.008; 0.001) | − 0.002 (− 0.006; 0.002) | |
| Model 2 | − 0.001 (− 0.005; 0.002) | – | − 0.002 (− 0.006; 0.002) | − 0.002 (− 0.006; 0.002) | − 0.002 (− 0.006; 0.002) | ||
| Bif–IMTmeanm13 | |||||||
| p50 | Model 1 | − 0.012 (− 0.022; − 0.002) | – | − 0.016 (− 0.028; − 0.004) | − 0.020 (− 0.031; − 0.009) | − 0.021 (− 0.032; − 0.01) | |
| Model 2 | − 0.010 (− 0.020; 0.001) | – | − 0.011 (− 0.023; 0.001) | − 0.016 (− 0.027; − 0.005) | − 0.016 (− 0.027; − 0.004) | ||
| ICA IMTmeanm20 | |||||||
| p50 | Model 1 | − 0.010 (− 0.016; − 0.004) | – | − 0.007 (− 0.014; 0.000) | − 0.011 (− 0.017; − 0.005) | − 0.011 (− 0.017; − 0.004) | |
| Model 2 | − 0.008 (− 0.015; − 0.001) | – | − 0.005 (− 0.012; 0.003) | − 0.009 (− 0.016; − 0.002) | − 0.008 (− 0.015; − 0.001) | ||
| CC–IMTmaxm2 | |||||||
| p50 | Model 1 | 0.004 (− 0.004; 0.012) | – | 0.003 (− 0.007; 0.013) | − 0.002 (− 0.011; 0.007) | − 0.004 (− 0.013; 0.005) | |
| Model 2 | 0.004 (− 0.005; 0.012) | – | 0.003 (− 0.007; 0.013) | 0.000 (− 0.009; 0.009) | − 0.003 (− 0.012; 0.006) | ||
| Bif–IMTmaxm13 | |||||||
| p50 | Model 1 | 0.001 (− 0.015; 0.017) | – | 0.000 (− 0.020; 0.019) | − 0.001 (− 0.019; 0.016) | 0.000 (− 0.018; 0.017) | |
| Model 2 | 0.004 (− 0.014; 0.022) | – | 0.005 (− 0.016; 0.027) | 0.004 (− 0.016; 0.024) | 0.002 (− 0.018; 0.023) | ||
| ICA IMTmaxm20 | |||||||
| p50 | Model 1 | − 0.020 (− 0.034; − 0.006) | – | − 0.022 (− 0.039; − 0.005) | − 0.020 (− 0.036; − 0.005) | − 0.028 (− 0.044; − 0.012) | |
| Model 2 | − 0.016 (− 0.031; − 0.002) | – | − 0.017 (− 0.034; 0.000) | − 0.016 (− 0.032; − 0.000) | − 0.022 (− 0.038; − 0.006) |
Results for all participants of the IMPROVE study for whom follow-up data on C-IMT were available (n = 3262). Number of observation for each analysis: IMTmean, Model 1,n = 3252; Model 2, n = 3211; IMT max, CC-IMT mean and CC-IMTmax: Model 1, n = 3260; Model 2, n = 3219; Bif-IMTmean and Bif-IMTmax: Model 1, n = 3249; Model 2, n = 3208; ICA-IMTmean and ICA-IMTmax: Model 1, n = 3242; Model 2, n = 3201
Model 1 Adjustments for sex and age; Model 2: Model 2 plus physical activity, education, smoking, latitude (categorical) and diet (continuous); m missing values
aFor women cut-off > 10 to < 20 g/day
bFor women cut-off > 20 g/day