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. 2020 Mar 11;78(1):227–247. doi: 10.1007/s00018-020-03485-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The early response to overnutrition in scWAT is characterized by loss of beige adipocytes. a Western blot for total OXPHOS proteins in scWAT from controls and HFD (n = 4) after 1 week. Vinculin is used as a loading control. b Mitochondrial DNA quantification. The y-axis represents the ratio between expression of a mitochondrial 16S and a genomic gene (ln11). c Representative images of UCP1 immunohistochemistry in control (top) and 1-week HFD (bottom). d)Cell size distribution calculated on sections of vWAT and scWAT from controls and 1-week HFD-treated mice (n = 5). Left panel: quantification of cells ranging from 0 to 50 µm². Right panel: the y-axis shows the probability density function for the kernel density estimation and the x-axis the cell size, ranging from 0 to 2000 µm² (n = 5). Data are represented as mean ± SD. Significance between the indicated groups was calculated using a two-tailed Student’s t test. *(p value < 0.05), **(p value < 0.01)