Table 2.
Associations of newborn measures with childhood glucose levels
| Variable | Birthweight | SSF | Cord C-peptide | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| βa | 95% CI | p value | βa | 95% CI | p value | βa | 95% CI | p value | |||
| Fasting glucose (mmol/l) | |||||||||||
| Model 1 | −0.008 | −0.022, 0.006 | 0.271 | −0.012 | −0.024, 0.000 | 0.057 | −0.004 | −0.016, 0.008 | 0.535 | ||
| Model 2 | −0.015 | −0.029, −0.001 | 0.041 | −0.019 | −0.031, −0.006 | 0.003 | −0.011 | −0.023, 0.001 | 0.067 | ||
| 30 min glucose (mmol/l) | |||||||||||
| Model 1 | −0.074 | −0.127, −0.020 | 0.007 | −0.067 | −0.112, −0.022 | 0.004 | 0.001 | −0.046, 0.047 | 0.977 | ||
| Model 2 | −0.103 | −0.157, −0.050 | <0.001 | −0.096 | −0.142, −0.051 | <0.001 | −0.030 | −0.078, 0.017 | 0.213 | ||
| 1 h glucose (mmol/l) | |||||||||||
| Model 1 | −0.094 | −0.162, −0.025 | 0.007 | −0.094 | −0.152, −0.035 | 0.002 | −0.005 | −0.064, 0.053 | 0.858 | ||
| Model 2 | −0.128 | −0.197, −0.059 | <0.001 | −0.128 | −0.187, −0.069 | <0.001 | −0.041 | −0.100, 0.019 | 0.180 | ||
| 2 h glucose (mmol/l) | |||||||||||
| Model 1 | −0.051 | −0.098, −0.005 | 0.031 | −0.036 | −0.075, 0.004 | 0.080 | 0.003 | −0.036, 0.042 | 0.887 | ||
| Model 2 | −0.069 | −0.116, −0.022 | 0.004 | −0.053 | −0.093, −0.013 | 0.01 | −0.016 | −0.055, 0.024 | 0.441 | ||
| Sum of glucose z scores | |||||||||||
| Model 1 | −0.176 | −0.284, −0.067 | 0.002 | −0.166 | −0.259, −0.073 | <0.001 | −0.011 | −0.103, 0.081 | 0.816 | ||
| Model 2 | −0.252 | −0.361, −0.143 | <0.001 | −0.242 | −0.335, −0.148 | <0.001 | −0.091 | −0.184, 0.003 | 0.058 | ||
Model 1 was adjusted for field centre, child age and sex, maternal variables at pregnancy OGTT (age, height, mean arterial pressure, parity [0 or 1+], smoking [yes/no], drinking alcohol [yes/no] and gestational age) and child’s family history of diabetes in first-degree relatives + maternal BMI at pregnancy OGTT. Model 2 was model 1 + maternal sum of glucose z scores at pregnancy OGTT
β values for child continuous outcomes are reported for newborn birthweight, SSF and cord C-peptide higher by 1 SD