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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Diabetologia. 2020 Nov 16;64(3):561–570. doi: 10.1007/s00125-020-05331-0

Table 2.

Associations of newborn measures with childhood glucose levels

Variable Birthweight SSF Cord C-peptide
βa 95% CI p value βa 95% CI p value βa 95% CI p value
Fasting glucose (mmol/l)
 Model 1 −0.008 −0.022, 0.006 0.271 −0.012 −0.024, 0.000 0.057 −0.004 −0.016, 0.008 0.535
 Model 2 −0.015 −0.029, −0.001 0.041 −0.019 −0.031, −0.006 0.003 −0.011 −0.023, 0.001 0.067
30 min glucose (mmol/l)
 Model 1 −0.074 −0.127, −0.020 0.007 −0.067 −0.112, −0.022 0.004 0.001 −0.046, 0.047 0.977
 Model 2 −0.103 −0.157, −0.050 <0.001 −0.096 −0.142, −0.051 <0.001 −0.030 −0.078, 0.017 0.213
1 h glucose (mmol/l)
 Model 1 −0.094 −0.162, −0.025 0.007 −0.094 −0.152, −0.035 0.002 −0.005 −0.064, 0.053 0.858
 Model 2 −0.128 −0.197, −0.059 <0.001 −0.128 −0.187, −0.069 <0.001 −0.041 −0.100, 0.019 0.180
2 h glucose (mmol/l)
 Model 1 −0.051 −0.098, −0.005 0.031 −0.036 −0.075, 0.004 0.080 0.003 −0.036, 0.042 0.887
 Model 2 −0.069 −0.116, −0.022 0.004 −0.053 −0.093, −0.013 0.01 −0.016 −0.055, 0.024 0.441
Sum of glucose z scores
 Model 1 −0.176 −0.284, −0.067 0.002 −0.166 −0.259, −0.073 <0.001 −0.011 −0.103, 0.081 0.816
 Model 2 −0.252 −0.361, −0.143 <0.001 −0.242 −0.335, −0.148 <0.001 −0.091 −0.184, 0.003 0.058

Model 1 was adjusted for field centre, child age and sex, maternal variables at pregnancy OGTT (age, height, mean arterial pressure, parity [0 or 1+], smoking [yes/no], drinking alcohol [yes/no] and gestational age) and child’s family history of diabetes in first-degree relatives + maternal BMI at pregnancy OGTT. Model 2 was model 1 + maternal sum of glucose z scores at pregnancy OGTT

a

β values for child continuous outcomes are reported for newborn birthweight, SSF and cord C-peptide higher by 1 SD