. Author manuscript; available in PMC: 2022 Feb 1.

Published in final edited form as: Pharmacol Res. 2020 Dec 28;164:105374. doi: 10.1016/j.phrs.2020.105374

Table 1.

Human dendritic cell subsets

DC type	Major function	Selective markers	Transcription factor dependence
cDC
cDC1	Antigen cross-presentation to CD8+ T cells	CD11c, Clec9, CD141	IRF8, BATF3, ID2,
cDC2A	CD4+ T cell polarization; antiinflammatory phenotype	CD1c, CLEC4A	IRF4, KLF4, Notch2
cDC2B	CD4+ T cell polarization; pro-inflammatory phenotype	CD14, CD32, CD36, CD163, CLEC10A	RORγT, ZEB2
pDC
	Type I IFN production upon encountering pathogens	CD123, BDCA-2, BDCA-4	Flt3L, E2–2, STAT3
moDC
	T cell stimulation; inflammatory cytokine secretion	CD11c, CD1c, CD1a, CD1b, FcεRl, CD206, CD14, CD11b	MAFB, KLF4

Abbreviations used: conventional DC (cDC), dendritic cell (DC), plasmacytoid DC (pDC), monocyte-derived DC (moDC), interferon (IFN)