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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2020 Dec 2;20(2):263–273. doi: 10.1158/1535-7163.MCT-20-0365

Figure 6. Radiosensitization of pancreatic tumor xenografts by AZD6738 and olaparib.

Figure 6.

Athymic nude mice bearing bilateral, flank MiaPaCa2 xenografts were treated with AZD6738 (25 mg/kg) and/or olaparib (50 mg/kg) one hour pre-RT (1.8 Gy/fraction), daily Monday through Friday for one cycle as indicated by the red bars on the graphs above. Tumor volumes were normalized to the first day of treatment (day 1) and are plotted as the mean tumor volume ± SE of n, 13–18 tumors per treatment group (A). The Kaplan-Meier plot (B) illustrates the proportion of tumors not tripled in volume within the full 80-day monitoring period. Statistical significance (P < 0.001) is indicated versus all other treatment groups. Treatment caused no obvious systemic toxicity as assessed by weight loss (C).