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. Author manuscript; available in PMC: 2021 Jul 18.
Published in final edited form as: Nat Genet. 2021 Jan 18;53(2):195–204. doi: 10.1038/s41588-020-00766-y

Figure 5. Tractor better localizes a top hit for Total Cholesterol.

Figure 5.

Runs on UKB admixed individuals with (A) standard GWAS model, (B) AFR-specific GWAS with Tractor, and (C) a meta-analysis of GWAS runs on deconvolved EUR and AFR tracts. Both Tractor runs pinpoint a lead SNP ~20kb downstream of the intronic standard GWAS top hit in DOCK6 spanning a better candidate gene, ANGPTL8. No significant signal was seen in the EUR segments. In all plots, point size is proportional to the number of samples included for that test, and color indicates r2 to the named lead SNP. The recombination rate is shown as a blue line generated from the AFR superpopulation of the 1000 Genomes Project in B, or the EUR superpopulation for other panels.