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. Author manuscript; available in PMC: 2021 Jul 18.
Published in final edited form as: Nat Genet. 2021 Jan 18;53(2):195–204. doi: 10.1038/s41588-020-00766-y

Extended Data Fig. 3. The contribution of absolute MAF and effect size to Tractor power.

Extended Data Fig. 3

All cases assume an 80/20 AFR/EUR admixture ratio, 10% disease prevalence, 12k cases/30k controls with an effect only in the AFR genetic background. In all panels, the solid line uses a traditional GWAS model while the dashed line is our LAI-incorporating Tractor model. (A,B): Equal effect in EUR and AFR with shifted absolute MAF. (C,D): effect only in AFR background. (A,C): MAF is set to 10% in both AFR and EUR. (B,D): MAF is set to 40% in both AFR and EUR. Panels E and F illustrate the heterogeneity in effect sizes required to observe gains in Tractor power over traditional GWAS assuming 20% MAF in both ancestries and an effect that is stronger in AFR with varying difference to the EUR effect.