Table 2:
Case data
| Case # | Age at LAAC & sex | Clinical / Neuroimaging findings | CHA2DS2 VASC | HAS BLED | Device used | Perioperative events | Bridging therapy | Long-term therapy | Follow-up duration | Outcome | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ICH | CMHs | Siderosis | Cognitive impairment | ||||||||||
| V-1 | 71 M | − | 22 | 1 gyrus | + | 3 | 4 | Watchman | None | SAPT | SAPT | 22m | Well |
| V-2 | 72 M | − | 19 | − | − | 4 | 4 | Watchman | None | DAPT | SAPT | 22m | Well |
| V-3 | 80 M | 2 | Pacemaker | + | 4 | 6 | Watchman | None | Warf | SAPT | 41m | Well | |
| V-4 | 50 F | − | >50 | − | + | 5 | 2 | Watchman | None | SAPT | SAPT | 30m | Well |
| V-5 | 76 F | 2 | >50 | 1 gyrus | − | 5 | 4 | Amulet | None | SAPT | None | 24m | Died1 |
| V-6 | 57 F | − | 22 | − | − | 4 | 4 | Ligation | None | SAPT | SAPT | 23m | Well |
| V-7 | 78 M | 1 | 5 | − | − | 4 | 4 | Watchman | None | SAPT | SAPT | 28m | Well |
| V-8 | 65 F | 1 | 21 | 3 gyri | − | 4 | 3 | Amulet | None | SAPT | SAPT | 28m | Well |
| V-9 | 82 F | − | >50 | − | + | 7 | 3 | Lariat | None | SAPT | SAPT | 13m | Stroke2 |
| V-10 | 81 M | 1 | Pacemaker | − | 4 | 5 | Watchman | None | DAPT | None | 33m | Well | |
| V-11 | 76 F | 1 | 3 | − | − | 8 | 5 | Watchman | None | Id-NOAC | SAPT | 22m | Well |
| V-12 | 69 M | − | 7 | − | − | 4 | 3 | Watchman | None | SAPT | SAPT | 42m | Well |
| V-13 | 58 M | 1 | 3 | − | − | 4 | 3 | Watchman | None | NOAC | DAPT | 40m | Well |
| V-14 | 70 M | 1 | 3 | − | − | 4 | 4 | Watchman | None | SAPT | SAPT | 15m | Well |
| V-15 | 65 M | − | 31 | − | + | 2 | 3 | Lariat | None | None | None | 13m | Well |
| V-16 | 75 F | − | 2 | − | − | 6 | 3 | Lariat | None | NOAC | SAPT | 11m | Well |
| V-17 | 79 F | − | 2 | − | − | 6 | 2 | Watchman | None | NOAC | None | 4m | Well |
| V-18 | 78 M | − | 4 | Diffuse | − | 7 | 4 | Lariat | None | SAPT | None | 15m | Well |
| V-19 | 77 M | − | 2 | Diffuse | − | 3 | 3 | Watchman | None | Id-NOAC | SAPT | 3m | Well |
| V-20 | 81 M | 1 | >50 | − | + | 4 | 3 | Watchman | None | SAPT | None | 4m | Died4 |
| V-21 | 73 M | − | 10 | 1 gyrus | + | 3 | 4 | Ligation | None | Warf | SAPT | 46m | Well |
| V-22 | 68 F | 1 | 0 | 2 gyri | − | 4 | 5 | Atriclip | None | SAPT | None | 72m | Well |
| B-23 | 75 F | 1 | 2 | − | − | 3 | 4 | Watchman | None | Warf | SAPT | 35m | Well |
| B-24 | 77 M | 1 | >50 | 2 gyri | − | 6 | 5 | Watchman | None | Warf | SAPT | 31m | Well |
| B-25 | 86 M | − | 7 | − | − | 7 | 5 | Watchman | Arrhyth.5 | Warf | SAPT | 24m | Well |
| B-26 | 80 M | 1 | 21 | − | + | 5 | 5 | Watchman | None | Warf | SAPT | 17m | ICH6 |
Abbreviations: LAAC = left atrial appendage occlusion, ICH = intracerebral hemorrhage, CMH = cerebral microhemorrhage, SAPT = single antiplatelet therapy, DAPT = dual antiplatelet therapy, Warf = warfarin, NOAC = novel oral anti-coagulant, Id-NOAC = low dose NOAC, m = month.
The patient died from heart failure.
The patient was treated with tPA for a stroke at 48 days post-procedure and a thrombus was visualized near the site of closure. Clinical outcome after this event was outstanding. The patient had end-stage Alzheimer’s disease and died shortly after suffering a concussion in a motor vehicle accident 13 months post-closure.
The patient died of localization related status epilepticus related to a previous intracerebral hemorrhage.
The patient had a brief episode of pulseless ventricular tachycardia without an adverse long-term outcome.
The patient suffered a traumatic, polycompartmenal intracranial hemorrhage 18 months after the procedure while on aspirin monotherapy. He quickly recovered to his baseline.