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. 2021 Jan;10(1):57–70. doi: 10.21037/tlcr-20-1062

Figure 6.

Figure 6

Overexpressed circ-AASDH enhanced tumor formation in vivo. (A,B,C,D,E,F) A549 cells stably transfected with overexpressed circ-AASDH were injected into nude mice. (A) The changes in the volume of the tumor. (B) Tumor weights and representative images of resected tumor masses were measured in nude mice treated with vector or circ-AASDH. (C,D,E) The circ-AASDH, miR-140-3p and E2F7 expression were examined in tumors. (F) The levels of E2F7 protein expression were tested. (G) The schematic diagram depicts that circ-AASDH, as the sponge of miR-140-3p, abates its inhibition on the expression of E2F7 to promote the proliferation and metastasis of lung adenocarcinoma. *P<0.05, **P<0.01.