Table 4. Multivariate competing risk analysis of variables associated with recurrence in 215 radically resected patients.
| Variables | Model 1 | Model 2 | Model 3 | |||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |||
| Brinkman index (>500 vs. ≤500) | 0.717 (0.489–1.050) | 0.088 | 0.729 (0.497–1.070) | 0.100 | 0.743 (0.509–1.080) | 0.120 | ||
| SII (>430.8 vs. ≤430.8) | 2.198 (1.258–3.840) | 0.005 | NA | NA | NA | NA | ||
| NLR (>2.1 vs. ≤2.1) | NA | NA | 1.414 (0.919–2.180) | 0.120 | NA | NA | ||
| PLR (>122.8 vs. ≤122.8) | NA | NA | NA | NA | 1.449 (0.950–2.210) | 0.085 | ||
| Tumor size (>5 vs. ≤5) | 1.393 (0.924–2.100) | 0.110 | 1.403 (0.930–2.120) | 0.110 | 1.381 (0.918–2.080) | 0.120 | ||
| TNM stage | ||||||||
| II vs. I | 1.230 (0.669–2.260) | 0.500 | 1.417 (0.779–2.580) | 0.250 | 1.309 (0.709–2.420) | 0.390 | ||
| III vs. I | 1.062 (0.559–2.020) | 0.850 | 1.261 (0.682–2.330) | 0.460 | 1.171 (0.620–2.210) | 0.630 | ||
| Necrosis (yes vs. no) | 1.442 (1.003–2.070) | 0.048 | 1.371 (0.951–1.980) | 0.091 | 1.463 (1.016–2.110) | 0.041 | ||
| Treatment pattern (surgery ± CT ± RT vs. surgery alone) | 1.525 (0.979–2.380) | 0.062 | 1.461 (0.943–2.260) | 0.090 | 1.504 (0.973–2.320) | 0.066 | ||
NA indicates not included in the model due to interference with the three indices, SII, the NLR and the PLR. HR, hazard ratio; CI, confidence interval; SII, systemic inflammation-immune index; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-lymphocyte ratio; CT, chemotherapy; RT, radiotherapy.