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Mutation concordance and sensitivity. (A) Overall mutation concordance between tissue and BALF EV DNAs was 56% for nonsynonymous mutations and increased to 81% for clinically significant mutations. (B) With mutations detected in tissue DNA as reference, by-variant sensitivity of nonsynonymous mutations in BALF EV DNA was 62% and increased to 83% for clinically significant mutations. BALF, bronchoalveolar lavage fluid; EV, extracellular vesicle.
