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. 2021 Jan;10(1):314–325. doi: 10.21037/tlcr-20-549

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2021 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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PFS and OS of RET-TKI-naïve patients treated with 450 mg BID alectinib. The Kaplan-Meier curves estimating PFS (A) and OS (B) of 25 RET-TKI-naïve NSCLC patients (3 in phase 1 and 22 in phase 2) are shown. OS, overall survival; RET-TKI, rearranged during transfection-tyrosine kinase inhibitor; PFS, progression-free survival; NSCLC, non-small cell lung cancer.