Table 1. Patient baseline characteristics.

Characteristics	Total (N=34)	Phase 1 (N=9)	Phase 2 (N=25)
Sex
Male	14	3	11
Female	20	6	14
Age
Median [range]	53 [30–78]	60 [39–75]	51 [30–78]
Smoking
Never	22	6	16
Former	12	3	9
Current	0	0	0
Histology
Adenocarcinoma	34	9	25
Other	0	0	0
Type of RET fusion
KIF5B	21	8	13
CCDC6	9	0	9
Unknown	4	1	3
ECOG PS
0	14	4	10
1	20	5	15
2	0	0	0
Brain metastases at baseline
Yes	8	4	4
No	26	5	21
Number of previous chemotherapy regimen
1	7	1	6
2	11	3	8
3 and more	16	5	11
Number of previous RET-TKI
0	29	7	22
1	3	2	1
2	2	0	2