Table 3. Pharmacokinetic parameter.
| Dose of alectinib | N | Tmax (h) | Cmax (ng/mL) | Cmin (ng/mL) | AUC0‒10 (ng·h/mL) | |
|---|---|---|---|---|---|---|
| Day 1 | 600 mg | 6 | 7.01 [3.98–9.98] | 366±102 [253–527] | 278±76 [201–417] | 1,710±587 [1,060–2,440] |
| 450 mg | 6 | 5.91 [4.0–7.93] | 165±93 [23–272] | 118±55 [12–165] | 927±517 [143–1,570] | |
| Day 15 | 600 mg | 3 | 5.77 [0–6.0] | 1,050±227 [788–1,210] | 911±281 [587–1,080] | 8,600±2,510 [5,800–10,600] |
| 450 mg | 5 | 7.97 [4.0–8.0] | 576±215 [304–840] | 483±192 [271–785] | 4,820±1,970 [2,440–7,460] |
Tmax = time to maximum concentration, median [min–max]. Cmax = maximum plasma concentration, arithmetic mean ± SD (standard deviation) [min–max]. Cmin = plasma concentration at 10 h after drug administration, arithmetic mean ± SD [min–max]. AUC0‒10 = area under plasma-concentration time curve from 0–10 h, arithmetic mean ± SD [min–max].