Table 3. Statistical comparison of representative human leucocyte antigen (HLA)-A,B,C allele frequency between anti-soluble liver antigen-/liver pancreas (anti-SLA/LP)-positive autoimmune hepatitis (AIH) patients and controls.
| Allele | Anti-SLA/LP positive (n=62) | Controls (n=500) | P value | Pc | OR | 95% CI | |||
|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | ||||||
| B*08:01 | 5 | 8.1 | 8 | 1.6 | 0.0089 | 0.1294 | 5.37 | 1.33–19.35 | |
| B*35:01 | 14 | 22.6 | 41 | 8.2 | 0.0011 | 0.0332 | 3.26 | 1.53–6.64 | |
| B*40:02 | 7 | 11.3 | 20 | 4.0 | 0.0211 | 0.2039 | 3.05 | 1.04–7.93 | |
| C*08:01 | 20 | 32.3 | 64 | 12.8 | 0.0002 | 0.0041 | 3.23 | 1.69–6.06 | |
Associations were tested by Fisher’s extract test using 2×2 contingency tables. OR and its 95% CI for the carrier of HLA were calculated in two groups. Pc values were calculated using Bonferroni’s procedure. HLA-A–C alleles detected at similar frequencies in AIH patients with anti-SLA/LP and normal controls are not shown. CI, confidence interval; OR, odds ratio; Pc, corrected P value.