Table 3. Multivariable Cox proportional hazard analysis for 180 days mortality (backward LR selection).
| Factor | Mortality at 30 days | Mortality at 90 days | Mortality at 180 days | Mortality at 1 year | Mortality at 3 years | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |||||
| Age (≥72 years) | – | n.s. | – | n.s. | 2.0 (0.8–5.0) | 0.127 | 2.7 (1.7–6.6) | 0.013 | 1.5 (1.0–2.3) | 0.073 | ||||
| Gender (male vs. female) | – | n.s. | – | n.s. | – | n.s. | 0.6 (0.4–1.1) | 0.084 | ||||||
| GOLD | ||||||||||||||
| GOLD II vs. III | 0.2 (0.0–2.7) | 0.207 | – | n.s. | 1.6 (0.2–13.4) | 0.631 | 0.8 (0.2–3.0) | 0.772 | 1.5 (0.5–3.2) | 0.418 | ||||
| GOLD II vs. IV | 0.9 (0.1–8.2) | 0.908 | – | n.s. | 3.8 (0.5–28.9) | 0.196 | 1.8 (0.5–5.9) | 0.360 | 2.3 (1.0–5.1) | 0.041 | ||||
| CRP (≥ 0.5 mg/L) | – | n.s. | – | n.s. | – | n.s. | ||||||||
| TnT (≥14 ng/L) | – | n.s. | – | n.s. | – | n.s. | ||||||||
| NT-proBNP (age-adjusted) | 3.1 (0.7–14.4) | 0.153 | 2.9 (1.0–8.7) | 0.054 | 2.2 (0.9–4.8) | 0.067 | 3.4 (1.7–6.6) | <0.001 | 2.0 (1.4–3.1) | 0.001 | ||||
| Fraction HSP27 urine excretion cut off (<0.845%) | 7.1 (1.6–32.3) | 0.011 | 4.3 (1.4–12.8) | 0.009 | 2.1 (0.9–5.1) | 0.080 | ||||||||
Data are presented as hazard ratios and 95% CI. GOLD, global initiative for chronic obstructive lung disease; CRP, C-reactive protein; cTnT, cardiac Troponin T; NT-proBNP, n-terminal pro-brain natriuretic peptide; HSP27, heat shock protein 27.