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. 2021 Jan;9(2):173. doi: 10.21037/atm-20-5044

Table 1. Characteristics of aberrant lncRNA in PCOS patients.

Species Specimen Gene Chromosome Expression pattern (up/down regulation) Identified functions Reference
Human Ovary NEAT1 11 Up Sponging mir-16, mir-483, mir-324-3p (47)
Promoting KGN cell proliferation
Granular cells ZFAS1 20 Up Sponging mir-129 (48)
Involving in cell proliferation and apoptosis
Regulate the P4 and E2 secretion
MALAT1 11 Down Sponging mir-125b, mir-203a (49)
Involving in cell proliferation and apoptosis
PVT1 8 Up Sponging mirna-17-5p (50)
Involving in cell proliferation and apoptosis
HCP5 6 Up Sponging mir27a-3p/IGF-1 (51)
Involving in cell proliferation and apoptosis
BANCR 9 Up Activating the p53 signaling (52)
Promoting cell apoptosis
LINC-01572:28 16 Up Impeding cell cycle (53)
Human HCG26 6 Up May involve in the proliferation (54)
Correlated with antral follicle count
OC1 9 Up Inhibiting aromatase mrna (55)
HUPCOS (ZSCAN2-5:15) 15 Up Inhibiting aromatase mrna (56)
Positively associated with follicular fluid testosterone
RP11-151A6.4 13 Up May involve in the lipid metabolism and the regulation of insulin (57)
PWRN2 15 Up Sponging mir-92b-3p (58,59)
Involved in oocyte nuclear maturation
Follicular fluid PVT1 8 Up Sponging mirna-17-5p (50)
RP11-2N1.2 18 Up Associated with serum androgen serum androgen (43)
CTC-338M12.6 5 Up
RP11-547D23.1 14 Up
RP11-834C11.4 12 Up
CTD-2034I21.1 16 Up Associated with serum LH levels
LINC01448 7 Up
AC005614.5 19 Up
B4GALT1-AS1 9 Up
FLJ33581 20 Up
Peripherial blood MIRLET7BHG 22 Up Positively related to BMI (60)
SRA 5 Up Positively related to BMI (61)
Involving in adiposity-related processes
CTBP1-AS 4 Up Closely related to the serum total testosterone (62)
GAS5 1 Down Positively associated with fasting plasma glucose levels (63)
H19 11 Up Related to the IR (64)
Xist X Down Negatively related with poor pregnant outcome (65)
SRLR 3 Up Involving in ovarian granulosa cell apoptosis (66)