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. 2021 Jan;9(2):173. doi: 10.21037/atm-20-5044

Table 2. Characteristics of aberrant lncRNA in different PCOS rodent models.

Species Models Specimen Gene Chromosome Expression pattern (up/down regulation) Identified functions Reference
Rat DHEA Granular cells HOTAIR 15 Up Function in HOTAIR/miR-130a/IGF1 ceRNA network (73)
Letrozole Uteri CD36–005 4 Up Promoting the proliferation of rat primary endometrial stromal cells (74)
Letrozole Ovary CD36-005 4 Up Function in CD36-005/miR-448-5p/Ltbp4 ceRNA network (75)
RT1-M3-1-002 20 Up Function in RT1-M3-1-002/miR-146a-5p/Csmd1 ceRNA network
May involve in cell adhesion molecules
Med12-002 X Up Involved in the androgen metabolic process and androgen receptor signaling pathway
Esr1-002 1 Up
Abcf2-004 4 Up /
Col6a3-201 9 Up /
Adgrv1-003 2 Up /
Grik2-001 20 Down /
Mouse DHEA Ovary SRA 18 Up Impeding the production of inflammation factors, angiogenetic factors as well as NF-κB signaling (76)
Changing insulin release
OC1 19 Up Regulating angiogenesis and inflammatory response via the NF-κB signaling pathway (43)