Table 2. Genotypes of KCNQ1 and KCNQ1OT1 polymorphisms with clinical outcome of gastric cancer patients.
| SNP ID | Genotype | Total/event | OS | Total/event | RFS | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Log-rank P | MST | HR (95% CI) | P | Log-rank P | MST | HR (95% CI) | P | ||||
| rs6578283 | AA | 421/140 | 62 | 0.804 | 421/179 | 41 | 0.503 | ||||
| GA | 211/77 | 0.773 | 57 | 0.958 (0.696–1.32) | 0.795 | 211/94 | 0.986 | 31 | 0.880 (0.660–1.174) | 0.386 | |
| GG | 32/9 | 47.3 | 1.234 (0.594–2.565) | 0.573 | 32/14 | 29 | 1.223 (0.670–2.231) | 0.512 | |||
| Dominant | 243/86 | 0.781 | 57 | 0.985 (0.725–1.339) | 0.925 | 243/108 | 0.87 | 30 | 0.918 (0.699–1.207) | 0.542 | |
| rs231348 | CC | 520/173 | 57 | 0.781 | 520/221 | 37 | 0.621 | ||||
| TC | 131/48 | 0.766 | 57 | 1.001 (0.704–1.451) | 0.953 | 131/59 | 0.343 | 32 | 0.996 (0.722–1.374) | 0.981 | |
| TT | 12/5 | 41.039 | 1.436 (0.524–3.937) | 0.481 | 12/7 | 17 | 1.561 (0.635–3.836) | 0.331 | |||
| Dominant | 143/53 | 0.754 | 57 | 1.040 (0.735–1.473) | 0.824 | 143/66 | 0.675 | 29 | 1.032 (0.757–1.406) | 0.842 | |
| rs760419 | AA | 304/105 | 62 | 0.174 | 304/131 | 31 | 0.302 | ||||
| GA | 281/90 | 0.517 | 59 | 0.787 (0.565–1.096) | 0.157 | 281/117 | 0.609 | 41 | 0.845 (0.632–1.128) | 0.253 | |
| GG | 79/31 | 39 | 1.165 (0.743–1.825) | 0.507 | 79/39 | 22 | 1.127 (0.752–1.687) | 0.563 | |||
| Dominant | 360/121 | 0.88 | 57 | 0.866 (0.638–1.176) | 0.358 | 360/156 | 0.953 | 37 | 0.904 (0.690–1.183) | 0.462 | |
| r231356 | TT | 406/138 | 57 | 0.827 | 406/172 | 40 | 0.358 | ||||
| TA | 228/79 | 0.961 | 57 | 1.038 (0.758–1.421) | 0.818 | 228/102 | 0.864 | 31 | 1.063 (0.806–1.403) | 0.664 | |
| AA | 30/9 | 46.776 | 1.289 (0.561–2.959) | 0.55 | 30/12 | 26 | 1.637 (0.827–3.241) | 0.157 | |||
| Dominant | 258/88 | 0.986 | 57 | 1.056 (0.778–1.433) | 0.726 | 258/115 | 0.613 | 31 | 1.102 (0.843–1.441) | 0.478 | |
| rs231354 | CC | 507/172 | 57 | 0.917 | 507/213 | 40 | 0.556 | ||||
| TC | 150/52 | 0.961 | 57 | 1.043 (0.740–1.470) | 0.812 | 150/71 | 0.636 | 29 | 1.150 (0.854–1.550) | 0.356 | |
| TT | 7/2 | 47.7 | 0.714 (0.099–5.167) | 0.739 | 7/3 | 17 | 0.582 (0.081–4.193) | 0.591 | |||
| Dominant | 157/54 | 0.925 | 57 | 1.032 (0.734–1.450) | 0.858 | 157/74 | 0.342 | 29 | 1.132 (0.842–1.521) | 0.413 | |
| rs231352 | CC | 509/172 | 57 | 0.914 | 509/214 | 40 | 0.545 | ||||
| TC | 148/52 | 0.936 | 57 | 1.045 (0.741–1.473) | 0.803 | 148/70 | 0.634 | 26 | 1.154 (0.857–1.555) | 0.346 | |
| TT | 7/2 | 47.7 | 0.714 (0.099–5.169) | 0.739 | 7/3 | 17 | 0.582 (0.081–4.195) | 0.591 | |||
| Dominant | 155/54 | 0.826 | 57 | 1.034 (0.736–1.453) | 0.848 | 155/73 | 0.34 | 26 | 1.135 (0.844–1.526) | 0.401 | |
| rs7939976 | AA | 550/193 | 57 | 0.014 | 550/243 | 32 | 0.010 | ||||
| GA | 112/31 | 0.048 | 47.832 | 0.929 (0.595–1.449) | 0.745 | 112/42 | <0.001 | 11.258 | 1.030 (0.704–1.508) | 0.878 | |
| GG | 2/2 | 4 | 20.749 (2.680–160.616) | 0.004 | 2/2 | 2 | 23.238 (3.026–178.479) | 0.002 | |||
| Dominant | 114/33 | 0.263 | 47.06 | 0.972 (0.628–1.504) | 0.897 | 114/44 | 0.322 | 40.59 | 1.063 (0.730–1.548) | 0.750 | |
| rs10832514 | AA | 517/174 | 57 | 0.155 | 517/219 | 37 | 0.081 | ||||
| GA | 139/49 | 0.809 | 41.823 | 1.359 (0.955–1.933) | 0.088 | 139/64 | 0.812 | 29 | 1.346 (0.984–1.840) | 0.063 | |
| GG | 8/3 | 36.964 | 1.821 (0.574–5.783) | 0.309 | 8/4 | 20 | 2.041 (0.750–5.558) | 0.163 | |||
| Dominant | 147/52 | 0.517 | 41.778 | 1.383 (0.982–1.949) | 0.064 | 147/68 | 0.522 | 29 | 1.379 (1.017–1.870) | 0.039 | |
| rs231361 | AA | 409/142 | 57 | 0.975 | 409/179 | 35 | 0.608 | ||||
| GA | 225/76 | 0.832 | 57 | 1.031 (0.752–1.413) | 0.849 | 225/96 | 0.981 | 37 | 1.038 (0.787–1.371) | 0.791 | |
| GG | 29/8 | 48.286 | 1.066 (0.432–2.633) | 0.89 | 29/12 | 38.76 | 1.437 (0.700–2.952) | 0.323 | |||
| Dominant | 254/84 | 0.768 | 44.71 | 1.034 (0.761–1.405) | 0.832 | 254/108 | 0.856 | 37 | 1.066 (0.814–1.395) | 0.642 | |
| rs231359 | AA | 410/143 | 57 | 0.943 | 410/176 | 40 | 0.617 | ||||
| CA | 224/75 | 0.788 | 57 | 0.950 (0.692–1.303) | 0.749 | 224/99 | 0.986 | 31 | 1.029 (0.780–1.357) | 0.840 | |
| CC | 29/8 | 48.286 | 1.038 (0.420–2.562) | 0.936 | 29/12 | 38.76 | 1.433 (0.698–2.945) | 0.327 | |||
| Dominant | 253/83 | 0.611 | 45.069 | 0.956 (0.703–1.300) | 0.775 | 253/111 | 0.865 | 31 | 1.056 (0.808–1.381) | 0.690 | |
| rs7128926 | AA | 547/192 | 57 | 0.012 | 547/242 | 32 | 0.010 | ||||
| GA | 115/32 | 0.05 | 47.667 | 0.863 (0.553–1.346) | 0.515 | 115/43 | <0.001 | 11.293 | 0.946 (0.647–1.385) | 0.777 | |
| GG | 2/2 | 4 | 20.585 (2.659–159.37) | 0.004 | 2/2 | 2 | 22.981 (2.992–176.541) | 0.003 | |||
| Dominant | 117/34 | 0.277 | 46.924 | 0.902 (0.583–1.395) | 0.642 | 117/45 | 0.315 | 40.64 | 0.976 (0.670–1.421) | 0.899 | |
KCNQ1, potassium voltage-gated channel KQT-like subfamily member 1; OS, overall survival; RFS, recurrence-free survival; MST, median survival time;