Table 3. Stratified analysis of the KCNQ1OT1 rs7128926 polymorphism with gastric cancer OS and RFS.
| Variables | Genotype | OS | RFS | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total/event | MST | HR (95% CI) | P | Total/event | MST | HR (95% CI) | P | |||
| Age1 | ||||||||||
| ≥55 | AA | 244/89 | 56 | 1 | 0.033 | 244/109 | 26 | 1 | 0.012 | |
| GA | 43/13 | 46.124 | 1.182 (0.622–2.243) | 0.61 | 43/17 | 40.207 | 1.282 (0.731–2.248) | 0.386 | ||
| GG | 2/2 | 4 | 16.444 (1.976–136.829) | 0.01 | 2/2 | 2 | 23.626 (2.808–198.769) | 0.004 | ||
| <55 | AA | 303/103 | 57 | 1 | 303/133 | 38 | 1 | |||
| GA | 72/19 | 46.867 | 0.759 (0.407–1.416) | 0.386 | 72/26 | 40.437 | 0.798 (0.473–1.3484) | 0.399 | ||
| GG | NA | NA | ||||||||
| Gender3 | ||||||||||
| Male | AA | 423/145 | 57 | 1 | 423/182 | 34 | 1 | |||
| GA | 88/22 | 49.604 | 0.760 (0.448–1.290) | 0.309 | 88/30 | 43.837 | 0.937 (0.597–1.470) | 0.776 | ||
| GG | 1/1 | 32 | 1/1 | 5 | ||||||
| Female | AA | 124/47 | 49 | 1 | 0.029 | 124/60 | 28 | 1 | 0.025 | |
| GA | 27/10 | 57 | 1.111 (0.483–2.555) | 0.805 | 27/13 | 18 | 0.912 (0.429–1.941) | 0.812 | ||
| GG | 1/1 | 4 | 20.590 (2.226–190.458) | 0.008 | 1/1 | 2 | 20.027 (2.225–180.28) | 0.008 | ||
| BMIa | ||||||||||
| <24 | AA | 142/42 | 44.062 | 1 | 142/55 | 42 | 1 | 0.18 | ||
| GA | 21/4 | 53.505 | 0.664 (0.233–1.891) | 0.443 | 21/5 | 49.591 | 0.493 (0.175–1.387) | 0.18 | ||
| GG | NA | NA | ||||||||
| ≥24 | AA | 338/114 | 45.062 | 1 | 0.026 | 338/140 | 50 | 1 | 0.012 | |
| GA | 77/20 | 46.393 | 0.926 (0.566–1.515) | 0.761 | 77/29 | 37 | 1.082 (0.715–1.638) | 0.709 | ||
| GG | 1/1 | 4 | 16.775 (2.129–132.171) | 0.007 | 1/1 | 2 | 22.835 (2.891–180.37) | 0.003 | ||
| H. pylori infectiona | ||||||||||
| Yes | AA | 331/108 | 46.099 | 1 | 0.028 | 331/128 | 41.846 | 1 | 0.017 | |
| GA | 60/17 | 47.416 | 0.946 (0.556–1.608) | 0.837 | 60/20 | 44.019 | 0.963 (0.593–1.565) | 0.879 | ||
| GG | 1/1 | 4 | 16.661 (2.099–132.243) | 0.008 | 1/1 | 2 | 20.207 (2.547–160.309) | 0.004 | ||
| No | AA | 149/48 | 35.121 | 1 | 0.329 | 149/67 | 25 | 1 | 0.706 | |
| GA | 38/7 | 36.069 | 0.661 (0.288–1.517) | 0.329 | 38/14 | 37 | 0.886 (0.471–1.665) | 0.706 | ||
| GG | NA | NA | ||||||||
| GA | 70/18 | 47.349 | 0.796 (0.427–1.486) | 0.457 | 70/25 | 40.684 | 0.857 (0.507–1.448) | 0.564 | ||
| GG | NA | NA | ||||||||
| ACTa | ||||||||||
| No | AA | 190/51 | 62 | 1 | 0.145 | 190/55 | 45.538 | 1 | 0.092 | |
| GA | 43/7 | 50.692 | 0.520 (0.216–1.252) | 0.145 | 43/8 | 49.297 | 0.495 (0.218–1.122) | 0.092 | ||
| GG | NA | NA | ||||||||
| Yes | AA | 357/141 | 48 | 1 | <0.001 | 357/187 | 24 | 1 | 0.002 | |
| GA | 71/25 | 57 | 1.184 (0.702–1.997) | 0.527 | 71/35 | 26 | 1.179 (0.763–1.822) | 0.458 | ||
| GG | 1/1 | 4 | 21.275 (2.295–197.256) | 0.007 | 1/1 | 2 | 20.576 (2.282–185.538) | 0.007 | ||
| Tumor sitea | ||||||||||
| Cardia | AA | 106/44 | 39 | 1 | 0.696 | 106/54 | 18 | 1 | 0.56 | |
| GA | 19/6 | 44.485 | 0.836 (0.340–2.055) | 0.696 | 19/8 | 37 | 0.794 (0.366–1.722) | 0.56 | ||
| GG | NA | NA | ||||||||
| Non-cardia | AA | 348/103 | 47.599 | 1 | 0.005 | 348/130 | 42.709 | 1 | 0.005 | |
| GA | 76/16 | 50.944 | 0.879 (0.514–1.504) | 0.638 | 76/25 | 43.566 | 1.086 (0.695–1.697) | 0.716 | ||
| GG | 1/1 | 4 | 32.242 (3.866–268.872) | 0.001 | 1/1 | 2 | 30.802 (3.815–248.709) | 0.001 | ||
| Tumor diametera | ||||||||||
| <5 | AA | 309/82 | 48.422 | 1 | 0.307 | 309/107 | 43.251 | 1 | 0.617 | |
| GA | 68/11 | 54.953 | 0.701 (0.354–1.386) | 0.307 | 68/21 | 46.036 | 1.138 (0.686–1.889) | 0.617 | ||
| GG | NA | NA | ||||||||
| ≥5 | AA | 227/106 | 33 | 1 | 0.019 | 227/131 | 18 | 1 | 0.005 | |
| GA | 44/20 | 38 | 1.005 (0.551–1.833) | 0.987 | 44/20 | 31 | 0.709 (0.383–1.311) | 0.273 | ||
| GG | 2/2 | 4 | 20.254 (2.481–165.381) | 0.005 | 2/2 | 2 | 26.207 (3.200–214.648) | 0.002 | ||
| Clinical stagea | ||||||||||
| Early | AA | 110/11 | 1 | 0.98 | 110/14 | 57.535 | 1 | 0.416 | ||
| GA | 30/0 | 0 | 0.98 | 30/1 | 62.87 | 0.421 (0.052–3.383) | 0.416 | |||
| GG | NA | NA | ||||||||
| Middle | AA | 384/143 | 48 | 1 | 0.036 | 384/184 | 25 | 1 | 0.035 | |
| GA | 78/27 | 57 | 0.882 (0.538–1.446) | 0.618 | 78/38 | 26 | 0.920 (0.609–1.390) | 0.692 | ||
| GG | 2/2 | 4 | 14.270 (1.810–112.511) | 0.012 | 2/2 | 2 | 14.416 (1.859–111.822) | 0.011 | ||
| Late | AA | 49/36 | 13 | 1 | 0.269 | 49/41 | 7 | 1 | 0.336 | |
| GA | 6/5 | 15 | 0.530 (0.172–1.635) | 0.269 | 6/4 | 6 | 0.531 (0.146–1.930) | 0.336 | ||
| GG | NA | NA | ||||||||
1, adjusted by gender; 3, adjusted by age. a, patient numbers may not add up to 100% of available subjects because of missing clinical data. KCNQ1, potassium voltage-gated channel KQT-like subfamily member 1; OS, overall survival; RFS, recurrence-free survival; MST, median survival time; ACT, adjuvant chemotherapy; R/M, recurrence/metastasis.