Table 4. Stratified analysis of the KCNQ1OT1 rs7939976 polymorphism with gastric cancer OS and RFS.
| Variables | Genotype | Total/event | OS | Total/event | RFS | ||||
|---|---|---|---|---|---|---|---|---|---|
| MST | HR (95% CI) | P | MST | HR (95% CI) | P2 | ||||
| Age1 | |||||||||
| ≥55 | AA | 245/89 | 56 | 1 | 0.031 | 245/109 | 26 | 1 | 0.009 |
| GA | 42/13 | 45.762 | 1.221 (0.643–2.32) | 0.542 | 42/17 | 37 | 1.378 (0.784–2.424) | 0.265 | |
| GG | 2/2 | 4 | 16.54 (1.988–137.641) | 0.009 | 2/2 | 2 | 24.131 (2.866–203.164) | 0.003 | |
| <55 | AA | 305/104 | 57 | 1 | 305/134 | 38 | 1 | ||
| GA | 70/18 | 47.349 | 0.796 (0.427–1.486) | 0.457 | 70/25 | 40.684 | 0.857 (0.507–1.448) | 0.564 | |
| GG | NA | NA | |||||||
| Gender3 | |||||||||
| Male | AA | 424/145 | 57 | 424/182 | 34 | ||||
| GA | 87/22 | 49.503 | 0.800 (0.470–1.360) | 0.41 | 87/30 | 43.725 | 1.018 (0.646–1.604) | 0.938 | |
| GG | 1/1 | 32 | 1/1 | 5 | |||||
| Female | AA | 126/48 | 49 | 1 | 0.025 | 126/61 | 28 | 1 | 0.026 |
| GA | 25/9 | 57 | 1.272 (0.552–2.929) | 0.572 | 25/12 | 18 | 1.025 (0.482–2.179) | 0.949 | |
| GG | 1/1 | 4 | 21.275 (2.295–197.256) | 0.007 | 1/1 | 2 | 20.576 (2.282–185.538) | 0.007 | |
| BMIa | |||||||||
| <24 | AA | 140/42 | 43.675 | 1 | 140/55 | 42 | 1 | ||
| GA | 23/4 | 54.558 | 0.594 (0.209–1.687) | 0.328 | 23/5 | 51.132 | 0.439 (0.156–1.229) | 0.117 | |
| GG | NA | NA | 0.439 (0.156–1.229) | 0.117 | |||||
| ≥24 | AA | 343/115 | 45.225 | 1 | 0.027 | 343/141 | 50 | 1 | 0.008 |
| GA | 72/19 | 45.961 | 1.043 (0.638–1.706) | 0.866 | 72/28 | 37 | 1.239 (0.818–1.876) | 0.313 | |
| GG | 1/1 | 4 | 16.941 (2.151–133.427) | 0.007 | 1/1 | 2 | 23.274 (2.948–183.783) | 0.003 | |
| H. pylori infectiona | |||||||||
| Yes | AA | 333/109 | 46.116 | 1 | 0.028 | 333/129 | 41.865 | 1 | 0.017 |
| GA | 58/16 | 47.68 | 1.028 (0.605–1.747) | 0.918 | 58/19 | 43.953 | 1.026 (0.632–1.666) | 0.916 | |
| GG | 1/1 | 4 | 16.764 (2.113–133.028) | 0.008 | 1/1 | 2 | 20.401 (2.572) | 0.004 | |
| No | AA | 150/448 | 35.046 | 1 | 0.382 | 150/67 | 25 | 1 | |
| GA | 37/7 | 36.294 | 0.689 (0.299–1.589) | 0.382 | 37/14 | 37 | 0.974 (0.512–1.850) | 0.935 | |
| GG | NA | NA | |||||||
| ACTa | |||||||||
| No | AA | 192/51 | 62 | 1 | 0.233 | 192/55 | 45.801 | 1 | 0.144 |
| GA | 41/7 | 50.023 | 0.587 (0.244–1.410) | 0.233 | 41/8 | 48.662 | 0.544 (0.240–1.230) | 0.144 | |
| GG | NA | NA | |||||||
| Yes | AA | 358/142 | 48 | 1 | <0.001 | 358/188 | 23 | 1 | 0.001 |
| GA | 70/24 | 57 | 1.268 (0.750–2.143) | 0.375 | 70/34 | 29 | 1.296 (0.837–2.007) | 0.244 | |
| GG | 2/2 | 4 | 89.316 (9.807–813.41) | <0.001 | 2/2 | 2 | 42.558 (5.243–345.483) | <0.001 | |
| Tumor sitea | |||||||||
| Cardia | AA | 105/44 | 35 | 1 | 0.383 | 105/54 | 18 | 1 | 0.331 |
| GA | 20/6 | 45.681 | 0.656 (0.254–1.693) | 0.383 | 20/8 | 37 | 0.667 (0.295–1.510) | 0.331 | |
| GG | NA | NA | |||||||
| Non-cardia | AA | 351/103 | 47.847 | 1 | 0.006 | 351/130 | 42.963 | 1 | 0.004 |
| GA | 73/16 | 50 | 0.993 (0.581–1.697) | 0.98 | 73/25 | 42.314 | 1.233 (0.789–1.924) | 0.357 | |
| GG | 1/1 | 4 | 32.587 (3.909–271.665) | 0.001 | 1/1 | 2 | 31.240 (3.870–252.142) | 0.001 | |
| Tumor diametera | |||||||||
| <5 | AA | 308/82 | 48.354 | 1 | 0.261 | 308/107 | 43.174 | 1 | 0.692 |
| GA | 69/11 | 55.114 | 0.675 (0.341–1.338) | 0.261 | 69/21 | 46.241 | 1.108 (0.666–1.844) | 0.692 | |
| GG | NA | NA | |||||||
| ≥5 | AA | 230/106 | 33 | 1 | 0.017 | 230/131 | 18 | 1 | 0.008 |
| GA | 41/20 | 38 | 1.159 (0.634–2.119) | 0.631 | 41/20 | 23 | 0.852 (0.458–1.585) | 0.613 | |
| GG | 2/2 | 4 | 20.426 (2.503–166.657) | 0.005 | 2/2 | 2 | 26.846 (3.278–219.865) | 0.002 | |
| Clinical stagea | |||||||||
| Early | AA | 109/11 | 1 | 0.976 | 109/14 | 57.497 | 1 | 0.378 | |
| GA | 31/0 | 0 | 0.976 | 31/1 | 62.958 | 0.393 (0.049–3.146) | 0.378 | ||
| GG | NA | NA | |||||||
| Middle | AA | 387/143 | 49 | 1 | 0.04 | 387/184 | 25 | 1 | 0.038 |
| GA | 75/27 | 57 | 0.959 (0.584–1.576) | 0.87 | 75/38 | 25 | 0.999 (0.661–1.511) | 0.997 | |
| GG | 2/2 | 4 | 14.354 (1.821–113.143) | 0.011 | 2/2 | 2 | 14.494 (1.869–112.392) | 0.011 | |
| Late | AA | 50/37 | 13 | 1 | 0.269 | 50/42 | 7 | 1 | 0.336 |
| GA | 5/4 | 17 | 0.530 (0.172–1.635) | 0.269 | 5/3 | 4 | 0.531 (0.146–1.930) | 0.336 | |
| GG | NA | NA | |||||||
1, adjusted by gender; 3, adjusted by age. a, patient numbers may not add up to 100% of available subjects because of missing clinical data. KCNQ1, potassium voltage-gated channel KQT-like subfamily member 1; OS, overall survival; RFS, recurrence-free survival; MST, median survival time; ACT, adjuvant chemotherapy; R/M, recurrence/metastasis.